信号通路： MAPK_ERK_Growth;MAPK_G_Protein;Tight junction;Regulates Actin and Cytoskeleton;
功能： disease:Defects in RRAS2 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome.,function:It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.,PTM:May be post-translationally modified by both palmitoylation and polyisoprenylation.,similarity:Belongs to the small GTPase superfamily. Ras family.,subcellular location:Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).,tissue specificity:Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.,
组织表达： Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.
科研货号： PLA007045
RRAS2 Polyclonal Antibody
Catalog NoPLA007045
Product information
基因名称： RRAS2 TC21
蛋白名称： Ras-related protein R-Ras2 (Ras-like protein TC21) (Teratocarcinoma oncogene)
信号通路： MAPK_ERK_Growth;MAPK_G_Protein;Tight junction;Regulates Actin and Cytoskeleton;
功能： disease:Defects in RRAS2 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome.,function:It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.,PTM:May be post-translationally modified by both palmitoylation and polyisoprenylation.,similarity:Belongs to the small GTPase superfamily. Ras family.,subcellular location:Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).,tissue specificity:Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.,
组织表达： Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.
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