信号通路： MAPK_ERK_Growth;MAPK_G_Protein;WNT;WNT-T CELLAxon guidance;VEGF;Focal adhesion;Adherens_Junction;Natural killer cell mediated cytotoxicity;B_Cell_Antigen;Fc epsilon RI;Regulates Actin and Cytoskeleton;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Viral myocarditis;
功能： function:Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.,induction:Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation.,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia.,subunit:Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D.,tissue specificity:Highest levels in brain, also detected in heart, placenta and pancreas.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery.
组织表达： Highest levels in brain, also detected in heart, placenta and pancreas.
信号通路： MAPK_ERK_Growth;MAPK_G_Protein;WNT;WNT-T CELLAxon guidance;VEGF;Focal adhesion;Adherens_Junction;Natural killer cell mediated cytotoxicity;B_Cell_Antigen;Fc epsilon RI;Regulates Actin and Cytoskeleton;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Viral myocarditis;
功能： function:Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.,induction:Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation.,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia.,subunit:Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D.,tissue specificity:Highest levels in brain, also detected in heart, placenta and pancreas.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery.
组织表达： Highest levels in brain, also detected in heart, placenta and pancreas.
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