功能： disease:A chromosomal aberration involving PICALM is found in diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with MLLT10.,function:Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.,similarity:Contains 1 ENTH (epsin N-terminal homology) domain.,subcellular location:Colocalized with clathrin in the Golgi area.,subunit:Binds clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol-4,5- bisphosphate.,tissue specificity:Expressed in all tissues examined.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane . Membrane, clathrin-coated pit . Golgi apparatus . Cytoplasmic vesicle, clathrin-coated vesicle . Nucleus . Colocalized with clathrin in the Golgi area (PubMed:10436022). Interaction with PIMREG may target PICALM to the nucleus in some cells (PubMed:16491119). .
功能： disease:A chromosomal aberration involving PICALM is found in diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with MLLT10.,function:Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.,similarity:Contains 1 ENTH (epsin N-terminal homology) domain.,subcellular location:Colocalized with clathrin in the Golgi area.,subunit:Binds clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol-4,5- bisphosphate.,tissue specificity:Expressed in all tissues examined.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane . Membrane, clathrin-coated pit . Golgi apparatus . Cytoplasmic vesicle, clathrin-coated vesicle . Nucleus . Colocalized with clathrin in the Golgi area (PubMed:10436022). Interaction with PIMREG may target PICALM to the nucleus in some cells (PubMed:16491119). .
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