功能： function:Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translated as Lys.,similarity:Belongs to the PSPC family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subcellular location:In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in a RNA-dependent manner. May cycles between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.,subunit:Forms heterodimers with NONO. Found in a RNP complex with CAT2 transcribed nuclear RNA (CTN-RNA). Interaction with NONO is required for its targeting to paraspeckles and perinucleolar caps. Interacts with SFPQ.,tissue specificity:Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nucleolus. Nucleus matrix . Cytoplasm . Nucleus speckle. In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycle between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.
组织表达： Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
科研货号： PLA006884
PSPC1 Polyclonal Antibody
Catalog NoPLA006884
Product information
基因名称： PSPC1 PSP1
蛋白名称： Paraspeckle component 1 (Paraspeckle protein 1)
功能： function:Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translated as Lys.,similarity:Belongs to the PSPC family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subcellular location:In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in a RNA-dependent manner. May cycles between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.,subunit:Forms heterodimers with NONO. Found in a RNP complex with CAT2 transcribed nuclear RNA (CTN-RNA). Interaction with NONO is required for its targeting to paraspeckles and perinucleolar caps. Interacts with SFPQ.,tissue specificity:Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nucleolus. Nucleus matrix . Cytoplasm . Nucleus speckle. In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycle between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.
组织表达： Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.
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