功能： disease:A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene.,disease:A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.,disease:Defects in NUP214 may be a cause of breast cancer.,domain:Contains FG repeats.,function:May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.,PTM:Probably glycosylated as it reacts with wheat germ agglutinin (WGA).,subcellular location:Cytoplasmic filaments.,subunit:Homodimer. Interacts with DDX19, NUP88, XPO1 and XPO5.,tissue specificity:Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nuclear pore complex . Cytoplasmic side of the nuclear pore complex. .
组织表达： Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.
功能： disease:A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene.,disease:A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.,disease:Defects in NUP214 may be a cause of breast cancer.,domain:Contains FG repeats.,function:May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.,PTM:Probably glycosylated as it reacts with wheat germ agglutinin (WGA).,subcellular location:Cytoplasmic filaments.,subunit:Homodimer. Interacts with DDX19, NUP88, XPO1 and XPO5.,tissue specificity:Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nuclear pore complex . Cytoplasmic side of the nuclear pore complex. .
组织表达： Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.
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