功能： disease:The deletion of 1 copy of the CHL1 may be responsible for mental defects in patients with 3p- syndrome. 3p- syndrome results from deletion of a terminal segment of the short arm of one chromosome 3 and is characterized by multiple congenital anomalies and mental retardation.,domain:The DGEA motif seems to be a recognition site for integrin.,domain:The FIG[AQ]Y motif seems to be an ankyrin recruitment region.,function:Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane.,PTM:Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors.,PTM:N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc).,PTM:O-glycosylated.,similarity:Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.,similarity:Contains 4 fibronectin type-III domains.,similarity:Contains 6 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Soluble forms produced by cleavage/shedding also exist.,subunit:May interact with L1CAM. May interact with ITGB1/ITGA1 heterodimer and ITGB1/ITGA2 heterodimer as well as with ANK3.,tissue specificity:Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein . Soluble forms produced by cleavage/shedding also exist. .; [Processed neural cell adhesion molecule L1-like protein]: Secreted, extracellular space, extracellular matrix .
组织表达： Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.
科研货号： PLA006806
CHL1 Polyclonal Antibody
Catalog NoPLA006806
Product information
基因名称： CHL1 CALL
蛋白名称： Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein]
功能： disease:The deletion of 1 copy of the CHL1 may be responsible for mental defects in patients with 3p- syndrome. 3p- syndrome results from deletion of a terminal segment of the short arm of one chromosome 3 and is characterized by multiple congenital anomalies and mental retardation.,domain:The DGEA motif seems to be a recognition site for integrin.,domain:The FIG[AQ]Y motif seems to be an ankyrin recruitment region.,function:Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane.,PTM:Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors.,PTM:N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc).,PTM:O-glycosylated.,similarity:Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.,similarity:Contains 4 fibronectin type-III domains.,similarity:Contains 6 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Soluble forms produced by cleavage/shedding also exist.,subunit:May interact with L1CAM. May interact with ITGB1/ITGA1 heterodimer and ITGB1/ITGA2 heterodimer as well as with ANK3.,tissue specificity:Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein . Soluble forms produced by cleavage/shedding also exist. .; [Processed neural cell adhesion molecule L1-like protein]: Secreted, extracellular space, extracellular matrix .
组织表达： Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.
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