功能： caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,enzyme regulation:Binding of TP53BP2 to the regulatory subunit NAE1 decreases neddylation activity.,function:Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.,miscellaneous:NAE1 and UBA3 correspond to the N-terminal and the C-terminal part of yeast UBA3. In yeast the two subunits form a single polypeptide chain.,pathway:Protein modification; protein neddylation.,similarity:Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.,subcellular location:Colocalizes with APP in lipid rafts.,subunit:Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M. Binds APP and TP53BP2.,tissue specificity:Ubiquitous in fetal tissues. Expressed throughout the adult brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane . Colocalizes with APP in lipid rafts.
组织表达： Ubiquitous in fetal tissues. Expressed throughout the adult brain.
科研货号： PLA006798
ULA1 Polyclonal Antibody
Catalog NoPLA006798
Product information
基因名称： NAE1 APPBP1 HPP1
蛋白名称： NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)
功能： caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,enzyme regulation:Binding of TP53BP2 to the regulatory subunit NAE1 decreases neddylation activity.,function:Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.,miscellaneous:NAE1 and UBA3 correspond to the N-terminal and the C-terminal part of yeast UBA3. In yeast the two subunits form a single polypeptide chain.,pathway:Protein modification; protein neddylation.,similarity:Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.,subcellular location:Colocalizes with APP in lipid rafts.,subunit:Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M. Binds APP and TP53BP2.,tissue specificity:Ubiquitous in fetal tissues. Expressed throughout the adult brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane . Colocalizes with APP in lipid rafts.
组织表达： Ubiquitous in fetal tissues. Expressed throughout the adult brain.
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