功能： domain:The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm.,function:Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.,similarity:Belongs to the MDFI family.,subcellular location:Isoform 1 localizes to the nucleolus and also shows a granular distribution in the cytoplasm. Isoform 2 is predominantly distributed throughout the cytoplasm, with only weak expression in the nucleus.,subunit:The C-terminus interacts with HIV-1 Tat and Rev, AXIN1, the histidine-rich region of CCNT1/CYCLIN T and weakly with LEF1.,tissue specificity:Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 1]: Nucleus, nucleolus. Also shows a granular distribution in the cytoplasm.; [Isoform 2]: Cytoplasm . Weak expression in the nucleus.
组织表达： Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine.
科研货号： PLA006753
MDFIC Polyclonal Antibody
Catalog NoPLA006753
Product information
基因名称： MDFIC
蛋白名称： MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC)
功能： domain:The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm.,function:Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.,similarity:Belongs to the MDFI family.,subcellular location:Isoform 1 localizes to the nucleolus and also shows a granular distribution in the cytoplasm. Isoform 2 is predominantly distributed throughout the cytoplasm, with only weak expression in the nucleus.,subunit:The C-terminus interacts with HIV-1 Tat and Rev, AXIN1, the histidine-rich region of CCNT1/CYCLIN T and weakly with LEF1.,tissue specificity:Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 1]: Nucleus, nucleolus. Also shows a granular distribution in the cytoplasm.; [Isoform 2]: Cytoplasm . Weak expression in the nucleus.
组织表达： Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine.
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