功能： catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,domain:LXXLL motifs 5 and 5 are essential for the association with ESR1 nuclear receptor.,function:Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.,miscellaneous:This gene mapped to a chromosomal region involved in duplications and translocations associated with cancer.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily.,similarity:Contains 1 post-SET domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SET domain.,similarity:Contains 5 PHD-type zinc fingers.,subunit:Component of the MLL2/MLL3 complex (also named ASCOM complex), at least composed of MLL2, MLL3, ASH2L, RBBP5, DPY30, NCOA6, WDR5, MEN1, KDM6A and PAXIP1/PTIP. Interacts with NFE2. Interacts with ESR1; interaction is direct.,tissue specificity:Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver.
科研货号： PLA006751
MLL2 Polyclonal Antibody
Catalog NoPLA006751
Product information
基因名称： MLL2 ALR KMT2D MLL4
蛋白名称： Histone-lysine N-methyltransferase MLL2 (EC 2.1.1.43) (ALL1-related protein) (Lysine N-methyltransferase 2D) (KMT2D) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
功能： catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,domain:LXXLL motifs 5 and 5 are essential for the association with ESR1 nuclear receptor.,function:Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.,miscellaneous:This gene mapped to a chromosomal region involved in duplications and translocations associated with cancer.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily.,similarity:Contains 1 post-SET domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SET domain.,similarity:Contains 5 PHD-type zinc fingers.,subunit:Component of the MLL2/MLL3 complex (also named ASCOM complex), at least composed of MLL2, MLL3, ASH2L, RBBP5, DPY30, NCOA6, WDR5, MEN1, KDM6A and PAXIP1/PTIP. Interacts with NFE2. Interacts with ESR1; interaction is direct.,tissue specificity:Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver.
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