功能： catalytic activity:UDP-galactose + beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide.,domain:The conserved DXD motif is involved in enzyme activity.,function:Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.,online information:GlycoGene database,online information:Lactosylceramide 4-alpha-galactosyltransferase,pathway:Protein modification; protein glycosylation.,polymorphism:Different combinations or absence of the P blood group system antigens define 5 different phenotypes: P1, P2, P1(k), P2(k), and p. Genetic variation in A4GALT determines the p phenotype, which is rare and does not express any antigens. It is also known as null phenotype; p individuals have antibodies against P, P1 and Pk antigens in their sera. These antibodies are clinically important because they can cause severe transfusion reactions and miscarriage.,similarity:Belongs to the glycosyltransferase 32 family.,tissue specificity:Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Golgi apparatus membrane ; Single-pass type II membrane protein .
组织表达： Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.
功能： catalytic activity:UDP-galactose + beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide.,domain:The conserved DXD motif is involved in enzyme activity.,function:Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.,online information:GlycoGene database,online information:Lactosylceramide 4-alpha-galactosyltransferase,pathway:Protein modification; protein glycosylation.,polymorphism:Different combinations or absence of the P blood group system antigens define 5 different phenotypes: P1, P2, P1(k), P2(k), and p. Genetic variation in A4GALT determines the p phenotype, which is rare and does not express any antigens. It is also known as null phenotype; p individuals have antibodies against P, P1 and Pk antigens in their sera. These antibodies are clinically important because they can cause severe transfusion reactions and miscarriage.,similarity:Belongs to the glycosyltransferase 32 family.,tissue specificity:Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Golgi apparatus membrane ; Single-pass type II membrane protein .
组织表达： Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.
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