信号通路： Cell adhesion molecules (CAMs);Antigen processing and presentation;Hematopoietic cell lineage;Intestinal immune network for IgA production;Type I diabetes mellitus;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Allograft rejection;Graft-versus-host disease;Viral myocarditis;
功能： disease:Allelic variation at the HLA-DRB1 locus is a major contributor to genetic predisposition for sarcoidosis [MIM:181000]. Sarcoidosis is a disease of unknown aetiology in which there are chronic inflammatory granulomatous lesions in lymph nodes and other organs.,polymorphism:The following alleles of DRB1-1 are known: DRB1*0101, DRB1*0102, DRB1*0103, DRB1*0104, DRB1*0105, DRB1*0106 and DRB1*0107. The sequence shown is that of DRB1*0101.,polymorphism:The following alleles of DRB1-11 are known: DRB1*1101, DRB1*1103 and DRB1*1104. The sequence shown is that of DRB1*1101. Allele DRB1*1101 is associated with self-limiting hepatitis C virus (HCV) infections [MIM:609532].,polymorphism:The following alleles of DRB1-4 are known: DRB1*0401, DRB1*0402, DRB1*0403, DRB1*0404 and DRB1*0411. The sequence shown is that of DRB1*0401.,polymorphism:The following alleles of DRB1-8 are known: DRB1*0801 (Dw8.1), DRB1*0802 (Dw8.2; DRB1L), DRB1*0803 (Dw8.3) and DRB1*0804. The sequence shown is that of DRB1*0801.,polymorphism:The only allele of DRB1-10 known is DRB1*1001 which is shown here.,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain and a beta chain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Autolysosome membrane . The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:18305173). Component of immunological synapses at the interface between T cell and APC (PubMed:29884618). .
组织表达： Expressed in professional APCs: monocyte/macrophages, dendritic cells and B cells (at protein level) (PubMed:31495665, PubMed:23783831, PubMed:19830726). Expressed in thymic epithelial cells (at protein level) (PubMed:23783831).
科研货号： PLA006623
2B1F Polyclonal Antibody
Catalog NoPLA006623
Product information
基因名称： HLA-DRB1 HLA-DRB2
蛋白名称： HLA class II histocompatibility antigen, DRB1-15 beta chain (DW2.2/DR2.2) (MHC class II antigen DRB1*15)
信号通路： Cell adhesion molecules (CAMs);Antigen processing and presentation;Hematopoietic cell lineage;Intestinal immune network for IgA production;Type I diabetes mellitus;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Allograft rejection;Graft-versus-host disease;Viral myocarditis;
功能： disease:Allelic variation at the HLA-DRB1 locus is a major contributor to genetic predisposition for sarcoidosis [MIM:181000]. Sarcoidosis is a disease of unknown aetiology in which there are chronic inflammatory granulomatous lesions in lymph nodes and other organs.,polymorphism:The following alleles of DRB1-1 are known: DRB1*0101, DRB1*0102, DRB1*0103, DRB1*0104, DRB1*0105, DRB1*0106 and DRB1*0107. The sequence shown is that of DRB1*0101.,polymorphism:The following alleles of DRB1-11 are known: DRB1*1101, DRB1*1103 and DRB1*1104. The sequence shown is that of DRB1*1101. Allele DRB1*1101 is associated with self-limiting hepatitis C virus (HCV) infections [MIM:609532].,polymorphism:The following alleles of DRB1-4 are known: DRB1*0401, DRB1*0402, DRB1*0403, DRB1*0404 and DRB1*0411. The sequence shown is that of DRB1*0401.,polymorphism:The following alleles of DRB1-8 are known: DRB1*0801 (Dw8.1), DRB1*0802 (Dw8.2; DRB1L), DRB1*0803 (Dw8.3) and DRB1*0804. The sequence shown is that of DRB1*0801.,polymorphism:The only allele of DRB1-10 known is DRB1*1001 which is shown here.,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain and a beta chain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Autolysosome membrane . The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:18305173). Component of immunological synapses at the interface between T cell and APC (PubMed:29884618). .
组织表达： Expressed in professional APCs: monocyte/macrophages, dendritic cells and B cells (at protein level) (PubMed:31495665, PubMed:23783831, PubMed:19830726). Expressed in thymic epithelial cells (at protein level) (PubMed:23783831).
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