功能： function:When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.,miscellaneous:Suppression of caspase activation by the BIRC5/HBXIP complex is increased in the presence of HBX.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the HBXIP family.,subunit:Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1. Interacts with hepatitis B virus (HBV) oncoprotein HBX C-terminus.,tissue specificity:Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Lysosome . Cytoplasm, cytosol .
组织表达： Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.
科研货号： PLA006618
HBXIP Polyclonal Antibody
Catalog NoPLA006618
Product information
基因名称： HBXIP XIP
蛋白名称： Hepatitis B virus X-interacting protein (HBV X-interacting protein) (HBX-interacting protein)
功能： function:When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.,miscellaneous:Suppression of caspase activation by the BIRC5/HBXIP complex is increased in the presence of HBX.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the HBXIP family.,subunit:Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently. Interacts with SUPV3L1. Interacts with hepatitis B virus (HBV) oncoprotein HBX C-terminus.,tissue specificity:Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Lysosome . Cytoplasm, cytosol .
组织表达： Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.
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