功能： catalytic activity:The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.,caution:It is uncertain whether Met-1, Met-9 or Met-16 is the initiator.,cofactor:Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity, but which is probably involved in the proper positioning of the enzyme along the DNA strand.,developmental stage:Expression levels are regulated during the cell cycle with increased levels during early and mid S-phase.,function:Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions.,similarity:Belongs to the nth/mutY family.,tissue specificity:Widely expressed with highest levels in heart and lowest levels in lung and liver.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Mitochondrion .
组织表达： Widely expressed with highest levels in heart and lowest levels in lung and liver.
科研货号： PLA006556
NTHL1 Polyclonal Antibody
Catalog NoPLA006556
Product information
基因名称： NTHL1 NTH1 OCTS3
蛋白名称： Endonuclease III-like protein 1 (EC 4.2.99.18)
功能： catalytic activity:The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.,caution:It is uncertain whether Met-1, Met-9 or Met-16 is the initiator.,cofactor:Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity, but which is probably involved in the proper positioning of the enzyme along the DNA strand.,developmental stage:Expression levels are regulated during the cell cycle with increased levels during early and mid S-phase.,function:Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions.,similarity:Belongs to the nth/mutY family.,tissue specificity:Widely expressed with highest levels in heart and lowest levels in lung and liver.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Mitochondrion .
组织表达： Widely expressed with highest levels in heart and lowest levels in lung and liver.
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