功能： function:E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated by MAP3K3.,PTM:Ubiquitinates itself upon phosphorylation.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 TRAF-type zinc finger.,similarity:Contains 7 WD repeats.,subcellular location:Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.,subunit:Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.,tissue specificity:Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasmic vesicle . Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
组织表达： Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
科研货号： PLA006547
TRAF7 Polyclonal Antibody
Catalog NoPLA006547
Product information
基因名称： TRAF7 RFWD1 RNF119
蛋白名称： E3 ubiquitin-protein ligase TRAF7 (EC 6.3.2.-) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (TNF receptor-associated factor 7)
功能： function:E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated by MAP3K3.,PTM:Ubiquitinates itself upon phosphorylation.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 TRAF-type zinc finger.,similarity:Contains 7 WD repeats.,subcellular location:Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.,subunit:Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.,tissue specificity:Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasmic vesicle . Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
组织表达： Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
在线咨询
湘公网安备