功能： domain:The coiled coil domains interact with the SB domain of TSG101.,domain:The PTAP motifs mediate the binding to UEV domains.,function:E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 5 LRR (leucine-rich) repeats.,subcellular location:Displays a punctuate distribution and localizes to a submembranal ring.,subunit:Interacts with TSG101.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Displays a punctuate distribution and localizes to a submembranal ring (PubMed:15256501). Localizes to intracellular bacterial pathogens (PubMed:23245322). .
组织表达： Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.
科研货号： PLA006537
LRSM1 Polyclonal Antibody
Catalog NoPLA006537
Product information
基因名称： LRSAM1 TAL UNQ6496/PRO21356
蛋白名称： E3 ubiquitin-protein ligase LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL)
功能： domain:The coiled coil domains interact with the SB domain of TSG101.,domain:The PTAP motifs mediate the binding to UEV domains.,function:E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 5 LRR (leucine-rich) repeats.,subcellular location:Displays a punctuate distribution and localizes to a submembranal ring.,subunit:Interacts with TSG101.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Displays a punctuate distribution and localizes to a submembranal ring (PubMed:15256501). Localizes to intracellular bacterial pathogens (PubMed:23245322). .
组织表达： Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.
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