功能： catalytic activity:ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.,cofactor:Divalent metal ions (calcium or magnesium).,function:Relieves DNA strain that arise during duplication of mitochondrial DNA.,miscellaneous:When a topoisomerase transiently breaks a DNA backbone bond, it simultaneously forms a protein-DNA link, in which a tyrosyl oxygen in the enzyme is joined to a DNA phosphorus at one end of the enzyme-severed DNA strand.,similarity:Belongs to the eukaryotic type I topoisomerase family.,tissue specificity:Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion .
组织表达： Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.
科研货号： PLA006509
TOP1M Polyclonal Antibody
Catalog NoPLA006509
Product information
基因名称： TOP1MT
蛋白名称： DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.99.1.2)
功能： catalytic activity:ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.,cofactor:Divalent metal ions (calcium or magnesium).,function:Relieves DNA strain that arise during duplication of mitochondrial DNA.,miscellaneous:When a topoisomerase transiently breaks a DNA backbone bond, it simultaneously forms a protein-DNA link, in which a tyrosyl oxygen in the enzyme is joined to a DNA phosphorus at one end of the enzyme-severed DNA strand.,similarity:Belongs to the eukaryotic type I topoisomerase family.,tissue specificity:Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Mitochondrion .
组织表达： Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.
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