功能： catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.,caution:Most tissues also express read-through transcripts from this gene into the upstream gene (Jmjd7), some of which may encode fusion proteins.,caution:This sequence was first thought to be an alternatively spliced isoform of Pla2g4b. It is derived from Jmjd7 which is located upstream of Pla2g4b. Most tissues also express read-through transcripts from Jmjd7 into the downstream Pla2g4b gene, some of which may encode fusion proteins combining the N-terminus of this protein with PLA2G4B protein.,domain:The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).,enzyme regulation:Stimulated by cytosolic Ca(2+).,function:Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine.,similarity:Contains 1 C2 domain.,similarity:Contains 1 JmjC domain.,similarity:Contains 1 PLA2c domain.,subcellular location:Translocates to membrane vesicles in a calcium-dependent fashion.,tissue specificity:Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 3]: Cytoplasm, cytosol . Mitochondrion membrane ; Peripheral membrane protein. Early endosome membrane ; Peripheral membrane protein. Translocates to membrane vesicles in a calcium-dependent fashion. .; [Isoform 5]: Cytoplasm, cytosol .
组织表达： Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas.
功能： catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.,caution:Most tissues also express read-through transcripts from this gene into the upstream gene (Jmjd7), some of which may encode fusion proteins.,caution:This sequence was first thought to be an alternatively spliced isoform of Pla2g4b. It is derived from Jmjd7 which is located upstream of Pla2g4b. Most tissues also express read-through transcripts from Jmjd7 into the downstream Pla2g4b gene, some of which may encode fusion proteins combining the N-terminus of this protein with PLA2G4B protein.,domain:The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).,enzyme regulation:Stimulated by cytosolic Ca(2+).,function:Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine.,similarity:Contains 1 C2 domain.,similarity:Contains 1 JmjC domain.,similarity:Contains 1 PLA2c domain.,subcellular location:Translocates to membrane vesicles in a calcium-dependent fashion.,tissue specificity:Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform 3]: Cytoplasm, cytosol . Mitochondrion membrane ; Peripheral membrane protein. Early endosome membrane ; Peripheral membrane protein. Translocates to membrane vesicles in a calcium-dependent fashion. .; [Isoform 5]: Cytoplasm, cytosol .
组织表达： Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas.
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