功能： disease:Defects in PDS5B may be the cause of some cancers including esophageal cancer.,function:Plays a role in androgen-induced proliferative arrest in prostate cells. Required for maintenance of sister chromatid cohesion during mitosis.,induction:By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum levels occur 18-20 hours after androgen exposure.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the PDS5 family.,similarity:Contains 1 HEAT repeat.,similarity:Contains 3 A.T hook DNA-binding domains.,subunit:Interacts with the cohesin complex.,tissue specificity:Widely expressed.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus .
组织表达： Widely expressed.
科研货号： PLA006301
PDS5B Polyclonal Antibody
Catalog NoPLA006301
Product information
基因名称： PDS5B APRIN AS3 KIAA0979
蛋白名称： Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3)
功能： disease:Defects in PDS5B may be the cause of some cancers including esophageal cancer.,function:Plays a role in androgen-induced proliferative arrest in prostate cells. Required for maintenance of sister chromatid cohesion during mitosis.,induction:By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum levels occur 18-20 hours after androgen exposure.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the PDS5 family.,similarity:Contains 1 HEAT repeat.,similarity:Contains 3 A.T hook DNA-binding domains.,subunit:Interacts with the cohesin complex.,tissue specificity:Widely expressed.,
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