功能： function:Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as HTATIP/TIP60, probably explains its trancription activation activity.,PTM:Phosphorylated following nuclear translocation. Phosphorylation at Tyr-546 enhances the transcription activation activity and reduces the affinity with RASD1/DEXRAS1.,similarity:Contains 1 WW domain.,similarity:Contains 2 PID domains.,subcellular location:In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP. Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus. Nuclear translocation is under the regulation of APP.,subunit:Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts (via PID domain 2) with APP (with the intracellular domain of the beta-amyloid precursor protein). Interacts (via PID domain 2) with RASD1/DEXRAS1; impairs the trancription activation activity. Interacts (via PID domain 1) with HTATIP/TIP60. Interacts (via the WW domain) with proline-rich regions of APBB1IP and ENAH (By similarity). Interacts (via the WW domain) with histone H2AX (when phosphorylated on 'Tyr-142). Interacts with MAPK8.,tissue specificity:Highly expressed in brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane . Cytoplasm . Nucleus . Cell projection, growth cone . Nucleus speckle . Colocalizes with TSHZ3 in axonal growth cone (By similarity). Colocalizes with TSHZ3 in the nucleus (PubMed:19343227). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP (PubMed:18468999). Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus (PubMed:18468999). Nuclear translocation is under the regulation of APP (PubMed:18468999). Colocalizes with NEK6 at the nuclear speckles (PubMed:17512906). Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). .
组织表达： Highly expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease. ; [Isoform 4]: Expressed preferentially in the brain.
科研货号： PLA006299
APBB1 Polyclonal Antibody
Catalog NoPLA006299
Product information
基因名称： APBB1 FE65 RIR
蛋白名称： Amyloid beta A4 precursor protein-binding family B member 1 (Protein Fe65)
功能： function:Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as HTATIP/TIP60, probably explains its trancription activation activity.,PTM:Phosphorylated following nuclear translocation. Phosphorylation at Tyr-546 enhances the transcription activation activity and reduces the affinity with RASD1/DEXRAS1.,similarity:Contains 1 WW domain.,similarity:Contains 2 PID domains.,subcellular location:In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP. Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus. Nuclear translocation is under the regulation of APP.,subunit:Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts (via PID domain 2) with APP (with the intracellular domain of the beta-amyloid precursor protein). Interacts (via PID domain 2) with RASD1/DEXRAS1; impairs the trancription activation activity. Interacts (via PID domain 1) with HTATIP/TIP60. Interacts (via the WW domain) with proline-rich regions of APBB1IP and ENAH (By similarity). Interacts (via the WW domain) with histone H2AX (when phosphorylated on 'Tyr-142). Interacts with MAPK8.,tissue specificity:Highly expressed in brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane . Cytoplasm . Nucleus . Cell projection, growth cone . Nucleus speckle . Colocalizes with TSHZ3 in axonal growth cone (By similarity). Colocalizes with TSHZ3 in the nucleus (PubMed:19343227). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP (PubMed:18468999). Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus (PubMed:18468999). Nuclear translocation is under the regulation of APP (PubMed:18468999). Colocalizes with NEK6 at the nuclear speckles (PubMed:17512906). Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). .
组织表达： Highly expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease. ; [Isoform 4]: Expressed preferentially in the brain.
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