蛋白名称： Amyloid beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1)
功能： domain:Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.,function:Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.,similarity:Contains 1 PID domain.,similarity:Contains 2 PDZ (DHR) domains.,subunit:Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Binds to the cytoplasmic domain of amyloid protein (APP).,tissue specificity:Brain and spinal cord.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Only about 5% of the protein is located in the nucleus.; [Isoform 2]: Golgi apparatus .
组织表达： Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen.
科研货号： PLA006298
APBA1 Polyclonal Antibody
Catalog NoPLA006298
Product information
基因名称： APBA1 MINT1 X11
蛋白名称： Amyloid beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1)
功能： domain:Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.,function:Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.,similarity:Contains 1 PID domain.,similarity:Contains 2 PDZ (DHR) domains.,subunit:Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Binds to the cytoplasmic domain of amyloid protein (APP).,tissue specificity:Brain and spinal cord.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Only about 5% of the protein is located in the nucleus.; [Isoform 2]: Golgi apparatus .
组织表达： Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen.
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