信号通路： Primary bile acid biosynthesis;Steroid hormone biosynthesis;Androgen and estrogen metabolism;Metabolism of xenobiotics by cytochrome P450;
功能： catalytic activity:Androsterone + NAD(P)(+) = 5-alpha-androstane-3,17-dione + NAD(P)H.,catalytic activity:Chlordecone alcohol + NADP(+) = chlordecone + NADPH.,function:Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.,polymorphism:The allele with Cys-145/Val-311 shows a three- to five-fold decrease in catalytic efficiency for xenobiotic and steroidal substrates compared to the Ser-145/Leu-311 allele.,PTM:The N-terminus is blocked.,similarity:Belongs to the aldo/keto reductase family.,subunit:Monomer.,tissue specificity:Liver specific.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, cytosol .
组织表达： Liver specific.
科研货号： PLA006288
AK1C4 Polyclonal Antibody
Catalog NoPLA006288
Product information
基因名称： AKR1C4 CHDR
蛋白名称： Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (3-alpha-HSD1) (3-alpha-hydroxysteroid dehydrogenase type I) (EC 1.1.1.50) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA)
信号通路： Primary bile acid biosynthesis;Steroid hormone biosynthesis;Androgen and estrogen metabolism;Metabolism of xenobiotics by cytochrome P450;
功能： catalytic activity:Androsterone + NAD(P)(+) = 5-alpha-androstane-3,17-dione + NAD(P)H.,catalytic activity:Chlordecone alcohol + NADP(+) = chlordecone + NADPH.,function:Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.,polymorphism:The allele with Cys-145/Val-311 shows a three- to five-fold decrease in catalytic efficiency for xenobiotic and steroidal substrates compared to the Ser-145/Leu-311 allele.,PTM:The N-terminus is blocked.,similarity:Belongs to the aldo/keto reductase family.,subunit:Monomer.,tissue specificity:Liver specific.,
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