功能： developmental stage:Expressed in fetal heart, lung, brain and to a lower extent liver.,disease:A chromosomal aberration involving AFF4 is found in acute lymphoblastic leukemia (ALL). Insertion ins(5;11)(q31;q13q23) that forms a MLL-AFF4 fusion protein.,function:May play a role in transcriptional regulation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the AF4 family.,subunit:Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb).,tissue specificity:Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Associates to transcriptionally active chromatin but not at snRNA genes. .
组织表达： Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain.
科研货号： PLA006280
AFF4 Polyclonal Antibody
Catalog NoPLA006280
Product information
基因名称： AFF4 AF5Q31 MCEF HSPC092
蛋白名称： AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)
功能： developmental stage:Expressed in fetal heart, lung, brain and to a lower extent liver.,disease:A chromosomal aberration involving AFF4 is found in acute lymphoblastic leukemia (ALL). Insertion ins(5;11)(q31;q13q23) that forms a MLL-AFF4 fusion protein.,function:May play a role in transcriptional regulation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the AF4 family.,subunit:Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb).,tissue specificity:Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Associates to transcriptionally active chromatin but not at snRNA genes. .
组织表达： Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain.
在线咨询
湘公网安备