功能: catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.,function:Converts phosphatidylinositol-3,4,5-triphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates.,miscellaneous:Active in the presence of octyl-glucoside or Triton X-100, but completely inhibited by CTAB.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Several sequencing problems.,similarity:Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type IV family.,subcellular location:Peripheral membrane protein associated with Golgi stacks.,tissue specificity:Detected in brain, heart, pancreas, testis and spleen.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Cytoplasm, cytoskeleton, cilium axoneme . Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, ruffle . Cytoplasm . Nucleus . Peripheral membrane protein associated with Golgi stacks. .
组织表达: Detected in brain, heart, pancreas, testis and spleen.
功能: catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.,function:Converts phosphatidylinositol-3,4,5-triphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates.,miscellaneous:Active in the presence of octyl-glucoside or Triton X-100, but completely inhibited by CTAB.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Several sequencing problems.,similarity:Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type IV family.,subcellular location:Peripheral membrane protein associated with Golgi stacks.,tissue specificity:Detected in brain, heart, pancreas, testis and spleen.,
相关产品: RS0001,RS0002,YM3028,YM3029
细胞定位: Cytoplasm, cytoskeleton, cilium axoneme . Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, ruffle . Cytoplasm . Nucleus . Peripheral membrane protein associated with Golgi stacks. .
组织表达: Detected in brain, heart, pancreas, testis and spleen.