功能： catalytic activity:8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.,developmental stage:In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.,function:Antimutagenic. Responsible for preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions.,polymorphism:A polymorphism between Met-1 and Met-19 removes a stop codon before the initiation codon for isoform p22 and gives rise to the production of isoform p26. The allele frequency of isoform p26 is about 20%.,PTM:The N-terminus is blocked.,similarity:Belongs to the Nudix hydrolase family.,tissue specificity:Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform p18]: Cytoplasm, cytosol . Mitochondrion matrix . Nucleus . Mostly present in cytosol (PubMed:7782328). A minor proportion is mitochondrial (PubMed:7782328). A very small amount of the protein is associated with nuclei (PubMed:7782328). .; [Isoform p26]: Mitochondrion matrix .
组织表达： Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
功能： catalytic activity:8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.,developmental stage:In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.,function:Antimutagenic. Responsible for preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions.,polymorphism:A polymorphism between Met-1 and Met-19 removes a stop codon before the initiation codon for isoform p22 and gives rise to the production of isoform p26. The allele frequency of isoform p26 is about 20%.,PTM:The N-terminus is blocked.,similarity:Belongs to the Nudix hydrolase family.,tissue specificity:Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform p18]: Cytoplasm, cytosol . Mitochondrion matrix . Nucleus . Mostly present in cytosol (PubMed:7782328). A minor proportion is mitochondrial (PubMed:7782328). A very small amount of the protein is associated with nuclei (PubMed:7782328). .; [Isoform p26]: Mitochondrion matrix .
组织表达： Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
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