信号通路： Calcium;Vascular smooth muscle contraction;Focal adhesion;Regulates Actin and Cytoskeleton;
功能： catalytic activity:ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.,disease:Defects in MYLK2 are a cause of cardiomyopathy familial hypertrophic (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,function:Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.,tissue specificity:Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
组织表达： Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
信号通路： Calcium;Vascular smooth muscle contraction;Focal adhesion;Regulates Actin and Cytoskeleton;
功能： catalytic activity:ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.,disease:Defects in MYLK2 are a cause of cardiomyopathy familial hypertrophic (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,function:Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.,tissue specificity:Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm. Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
组织表达： Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
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