功能： function:Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.,similarity:Contains 1 G-patch domain.,similarity:Contains 1 R3H domain.,subunit:Interacts with NF-kappa-B.,tissue specificity:Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nucleolus .
组织表达： Widely and constitutively expressed (PubMed:10562553). Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney (PubMed:10562553).
功能： function:Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.,similarity:Contains 1 G-patch domain.,similarity:Contains 1 R3H domain.,subunit:Interacts with NF-kappa-B.,tissue specificity:Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nucleolus .
组织表达： Widely and constitutively expressed (PubMed:10562553). Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney (PubMed:10562553).
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