首页 > 抗体 > 一抗 > 其它 > TLR5 Polyclonal Antibody
TLR5 Polyclonal Antibody
商品货号: PLA005916
适 应 性: 人,小鼠
WB ELISA
¥600元
规格:
在线咨询
MSDS
说明书
商品描述
  • 基因名称: TLR5 TIL3
  • 蛋白名称: Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
  • Human_gene_id: 7100
  • Human_swiss_prot_no: O60602
  • Human_swiss_link: https://www.uniprot.org/uniprotkb/O60602/entry
  • Mouse_swiss_prot_no: Q9JLF7
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q9JLF7
  • 特异性: TLR5 Polyclonal Antibody detects endogenous levels of protein.
  • 组成: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000 ELISA 1:5000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 实测条带: 94kD
  • 信号通路: Toll_Like;Pathogenic Escherichia coli infection;
  • 功能: disease:Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1) [MIM:601744]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.,polymorphism:Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by Legionella pneumophila [MIM:608556]. It also provides protection against systemic lupus erythematosus.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 15 LRR (leucine-rich) repeats.,subunit:Binds MYD88 via their respective TIR domains.,tissue specificity:Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cell membrane ; Single-pass type I membrane protein .
  • 组织表达: Highly expressed on the basolateral surface of intestinal epithelia (PubMed:11489966). Expressed also in other cells such as lung epithelial cells (PubMed:11489966, PubMed:18490781).
  • 科研货号: PLA005916
TLR5 Polyclonal Antibody
Catalog No PLA005916
Product information
  • 基因名称: TLR5 TIL3
  • 蛋白名称: Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
  • Human_gene_id: 7100
  • Human_swiss_prot_no: O60602
  • Human_swiss_link: https://www.uniprot.org/uniprotkb/O60602/entry
  • Mouse_swiss_prot_no: Q9JLF7
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/Q9JLF7
  • 特异性: TLR5 Polyclonal Antibody detects endogenous levels of protein.
  • 组成: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000 ELISA 1:5000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 实测条带: 94kD
  • 信号通路: Toll_Like;Pathogenic Escherichia coli infection;
  • 功能: disease:Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1) [MIM:601744]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.,polymorphism:Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by Legionella pneumophila [MIM:608556]. It also provides protection against systemic lupus erythematosus.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 15 LRR (leucine-rich) repeats.,subunit:Binds MYD88 via their respective TIR domains.,tissue specificity:Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cell membrane ; Single-pass type I membrane protein .
  • 组织表达: Highly expressed on the basolateral surface of intestinal epithelia (PubMed:11489966). Expressed also in other cells such as lung epithelial cells (PubMed:11489966, PubMed:18490781).
  • 科研货号: PLA005916
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
普拉特泽实验室电话助手

4006916686

扫码咨询