功能： function:Putative regulatory subunit of protein phospatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.,similarity:Contains 27 ANK repeats.,subcellular location:Seems to be excluded from nucleoli.,subunit:Protein phospatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, SAPS1 and SAPS3.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nucleoplasm . Seems to be excluded from nucleoli.
组织表达： Amygdala,Brain,PCR rescued clones,Testis,
科研货号： PLA005901
ANR28 Polyclonal Antibody
Catalog NoPLA005901
Product information
基因名称： ANKRD28 KIAA0379
蛋白名称： Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK)
功能： function:Putative regulatory subunit of protein phospatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.,similarity:Contains 27 ANK repeats.,subcellular location:Seems to be excluded from nucleoli.,subunit:Protein phospatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, SAPS1 and SAPS3.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus, nucleoplasm . Seems to be excluded from nucleoli.
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