Phospho ERK 1/2 (Y222/205)Mouse Monoclonal Antibody(4G3)

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商品货号： PLA005836

适应性： 人,大鼠,小鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： MAPK1/MAPK3
蛋白名称： MAPK1/MAPK3
Human_gene_id： 5594/5595
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5594/5595
Human_swiss_prot_no： P27361/P28482
Human_swiss_link： http://www.uniprot.org/uniprotkb/P27361/entry
特异性： Phospho-ERK 1/2 (Y222/205)protein detects endogenous levels of MAPK1/MAPK3
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Monoclonal, Mouse
稀释： IHC-p 1:100-200. IF 1:50-200
纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MAPK1/MAPK3
实测条带： 44,42kD
信号通路： MAPK_ERK_Growth;MAPK_G_Protein;ErbB_HER;Chemokine;Oocyte meiosis;mTOR;Vascular smooth muscle contraction;Dorso-ventral axis formation;TGF-beta;Axon guidance;VEGF;Focal adhesion;Adherens_Junction;Gap junction;Toll_Like;NOD-like receptor;Natural killer cell mediated cytotoxicity;T_Cell_Receptor;B_Cell_Antigen;Fc epsilon RI;Fc gamma R-mediated phagocytosis;Long-term potentiation;Neurotrophin;Long-term depression;Regulates Actin and Cytoskeleton;Insulin_Receptor;GnRH;Progesterone-mediated oocyte maturation;Melanogenesis;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Alzheimer's disease;Prion diseases;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Thyroid cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by tyrosine phosphorylation in response to insulin and NGF.,function:Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).,PTM:Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MORG1 (By similarity). Binds to HIV-1 Nef. This interaction inhibits its kinase activity. Interacts with HSF4 and NISCH.,
相关产品： YT1625,YT1624,YT1623,YP1197,YP0101,YP0100,YM3677,YM3632,YM3518,YM3516,KA3252C,KA1568C,KA1567C
细胞定位： Cytoplasm . Nucleus. Membrane, caveola . Cell junction, focal adhesion . Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905). PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (By similarity). .
组织表达： Epithelium,Eye,Hepatoma,Human cervix,Lymph,
科研货号： PLA005836

Phospho ERK 1/2 (Y222/205)Mouse Monoclonal Antibody(4G3)

Catalog No PLA005836

Product information

基因名称： MAPK1/MAPK3
蛋白名称： MAPK1/MAPK3
Human_gene_id： 5594/5595
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5594/5595
Human_swiss_prot_no： P27361/P28482
Human_swiss_link： http://www.uniprot.org/uniprotkb/P27361/entry
特异性： Phospho-ERK 1/2 (Y222/205)protein detects endogenous levels of MAPK1/MAPK3
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Monoclonal, Mouse
稀释： IHC-p 1:100-200. IF 1:50-200
纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MAPK1/MAPK3
实测条带： 44,42kD
信号通路： MAPK_ERK_Growth;MAPK_G_Protein;ErbB_HER;Chemokine;Oocyte meiosis;mTOR;Vascular smooth muscle contraction;Dorso-ventral axis formation;TGF-beta;Axon guidance;VEGF;Focal adhesion;Adherens_Junction;Gap junction;Toll_Like;NOD-like receptor;Natural killer cell mediated cytotoxicity;T_Cell_Receptor;B_Cell_Antigen;Fc epsilon RI;Fc gamma R-mediated phagocytosis;Long-term potentiation;Neurotrophin;Long-term depression;Regulates Actin and Cytoskeleton;Insulin_Receptor;GnRH;Progesterone-mediated oocyte maturation;Melanogenesis;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;Alzheimer's disease;Prion diseases;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Thyroid cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Non-small cell lung cancer;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by tyrosine phosphorylation in response to insulin and NGF.,function:Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).,PTM:Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MORG1 (By similarity). Binds to HIV-1 Nef. This interaction inhibits its kinase activity. Interacts with HSF4 and NISCH.,
相关产品： YT1625,YT1624,YT1623,YP1197,YP0101,YP0100,YM3677,YM3632,YM3518,YM3516,KA3252C,KA1568C,KA1567C
细胞定位： Cytoplasm . Nucleus. Membrane, caveola . Cell junction, focal adhesion . Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905). PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (By similarity). .
组织表达： Epithelium,Eye,Hepatoma,Human cervix,Lymph,
科研货号： PLA005836

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