PCNA Monoclonal Antibody(12D10), HRP Conjugated

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商品货号： PLA005520

适应性： 人,大鼠,小鼠

￥600元

规格：

40μL 100μL 200μL

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说明书

商品描述

发货日期： 14
基因名称： PCNA
蛋白名称： Proliferating cell nuclear antigen
Human_gene_id： 5111
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5111
Human_swiss_prot_no： P12004
Human_swiss_link： https://www.uniprot.org/uniprotkb/P12004/entry
特异性： PCNA Monoclonal Antibody(12D10) HRP Conjugated, specially designed for your Western blot analysis.
组成： Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol.
来源： Monoclonal, Mouse IgG1
稀释： Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:5000, IHC 1:200.
纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
浓度： 1mg/ml
储存： Stable for one year at -15°C to -25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
说明书： 1
其他名称： PCNA; Proliferating cell nuclear antigen; PCNA; Cyclin
实测条带： 30-33kd
信号通路： DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能： disease:Antibodies are present in sera from patients with systemic lupus erythematosus.,function:This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.,online information:PCNA entry,PTM:Upon methyl methanesulfonate-induced DNA damage, mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases RNF8 and SHPRH, which are required for DNA repair.,similarity:Belongs to the PCNA family.,subunit:Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH, POLK, DNMT1, ERCC5/XPG, FEN1, CDC6, APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B/WSTF; the interaction is direct.,
相关产品： YT6075,YT3617,YM6211,YM6090,YM3031,YM2139,YM2138,YM2137,YM2136,YM2135,YM2134,YM2133,YM2132,YM2131,YM2130,YM2129,YM2128,KA3356C
细胞定位： Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .
组织表达： Bone marrow,Fetal brain cortex,Lung,Placenta,
科研货号： PLA005520

PCNA Monoclonal Antibody(12D10), HRP Conjugated

Catalog No PLA005520

Product information

发货日期： 14
基因名称： PCNA
蛋白名称： Proliferating cell nuclear antigen
Human_gene_id： 5111
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5111
Human_swiss_prot_no： P12004
Human_swiss_link： https://www.uniprot.org/uniprotkb/P12004/entry
特异性： PCNA Monoclonal Antibody(12D10) HRP Conjugated, specially designed for your Western blot analysis.
组成： Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol.
来源： Monoclonal, Mouse IgG1
稀释： Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:5000, IHC 1:200.
纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
浓度： 1mg/ml
储存： Stable for one year at -15°C to -25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
说明书： 1
其他名称： PCNA; Proliferating cell nuclear antigen; PCNA; Cyclin
实测条带： 30-33kd
信号通路： DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能： disease:Antibodies are present in sera from patients with systemic lupus erythematosus.,function:This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.,online information:PCNA entry,PTM:Upon methyl methanesulfonate-induced DNA damage, mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases RNF8 and SHPRH, which are required for DNA repair.,similarity:Belongs to the PCNA family.,subunit:Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH, POLK, DNMT1, ERCC5/XPG, FEN1, CDC6, APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B/WSTF; the interaction is direct.,
相关产品： YT6075,YT3617,YM6211,YM6090,YM3031,YM2139,YM2138,YM2137,YM2136,YM2135,YM2134,YM2133,YM2132,YM2131,YM2130,YM2129,YM2128,KA3356C
细胞定位： Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .
组织表达： Bone marrow,Fetal brain cortex,Lung,Placenta,
科研货号： PLA005520

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