Lamin B1 Monoclonal Antibody(7C11), AbFluor™ 350 Conjugated

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商品货号： PLA005481

适应性： 人,大鼠,小鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

发货日期： 14
基因名称： LMNB1
蛋白名称： Lamin-B1
Human_gene_id： 4001
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4001
Human_swiss_prot_no： P20700
Human_swiss_link： https://www.uniprot.org/uniprotkb/P20700/entry
特异性： Lamin B1 Monoclonal Antibody(7C11) AbFluor™ 350 Conjugated specially designed for your Immunofluorescence analysis.
组成： Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol.
来源： Monoclonal, Mouse IgG
稀释： Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300, IF 1:200.
纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
浓度： 1mg/ml
储存： Stable for one year at -15°C to -25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Store in dark.
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： LMNB1
功能： disease:Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.,function:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.,miscellaneous:The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.,PTM:B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.,similarity:Belongs to the intermediate filament family.,subunit:Interacts with lamin-associated polypeptides IA, IB and 2.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus lamina .
组织表达： Brain,Cajal-Retzius cell,Epithelium,Eye,Fetal brain cortex,Ovarian carcinoma,Placenta,Uterus,
科研货号： PLA005481

Lamin B1 Monoclonal Antibody(7C11), AbFluor™ 350 Conjugated

Catalog No PLA005481

Product information

发货日期： 14
基因名称： LMNB1
蛋白名称： Lamin-B1
Human_gene_id： 4001
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4001
Human_swiss_prot_no： P20700
Human_swiss_link： https://www.uniprot.org/uniprotkb/P20700/entry
特异性： Lamin B1 Monoclonal Antibody(7C11) AbFluor™ 350 Conjugated specially designed for your Immunofluorescence analysis.
组成： Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol.
来源： Monoclonal, Mouse IgG
稀释： Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300, IF 1:200.
纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
浓度： 1mg/ml
储存： Stable for one year at -15°C to -25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Store in dark.
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： LMNB1
功能： disease:Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.,function:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.,miscellaneous:The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.,PTM:B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.,similarity:Belongs to the intermediate filament family.,subunit:Interacts with lamin-associated polypeptides IA, IB and 2.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus lamina .
组织表达： Brain,Cajal-Retzius cell,Epithelium,Eye,Fetal brain cortex,Ovarian carcinoma,Placenta,Uterus,
科研货号： PLA005481

Hunan UPT Biotechnology Co.,Ltd

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