其他名称： 60 kDa chaperonin;60 kDa heat shock protein mitochondrial;60 kDa heat shock protein, mitochondrial;CH60_HUMAN;Chaperonin 60;Chaperonin;Chaperonin, 60-KD;CPN 60;CPN60;fa04a05;GROEL;GroEL Homolog;Heat shock 60kD protein 1 chaperonin;Heat shock 60kDa protein 1;Heat shock protein 1 (chaperonin);Heat Shock Protein 60;Heat shock protein 65;HLD4;Hsp 60;HSP 65;HSP-60;HSP60;HSP65;HSPD 1;HSPD1;HuCHA60;Mitochondrial matrix protein P1;P60 lymphocyte protein;Short heat shock protein 60 Hsp60s1;Spastic paraplegia 13;SPG 13;SPG13.
实测条带： 60kD
信号通路： RNA degradation;Type I diabetes mellitus;
功能： disease:Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13) [MIM:605280]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.,disease:Defects in HSPD1 are the cause of leukodystrophy hypomyelinating type 4 (HLD4) [MIM:612233]; also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. HLD4 is a severe autosomal recessive hypomyelinating leukodystrophy. Clinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first 2 decades of life.,function:Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.,similarity:Belongs to the chaperonin (HSP60) family.,similarity:Belongs to the TCP-1 chaperonin family.,subunit:Interacts with HBV protein X and HTLV-1 protein p40tax.,
其他名称： 60 kDa chaperonin;60 kDa heat shock protein mitochondrial;60 kDa heat shock protein, mitochondrial;CH60_HUMAN;Chaperonin 60;Chaperonin;Chaperonin, 60-KD;CPN 60;CPN60;fa04a05;GROEL;GroEL Homolog;Heat shock 60kD protein 1 chaperonin;Heat shock 60kDa protein 1;Heat shock protein 1 (chaperonin);Heat Shock Protein 60;Heat shock protein 65;HLD4;Hsp 60;HSP 65;HSP-60;HSP60;HSP65;HSPD 1;HSPD1;HuCHA60;Mitochondrial matrix protein P1;P60 lymphocyte protein;Short heat shock protein 60 Hsp60s1;Spastic paraplegia 13;SPG 13;SPG13.
实测条带： 60kD
信号通路： RNA degradation;Type I diabetes mellitus;
功能： disease:Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13) [MIM:605280]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.,disease:Defects in HSPD1 are the cause of leukodystrophy hypomyelinating type 4 (HLD4) [MIM:612233]; also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. HLD4 is a severe autosomal recessive hypomyelinating leukodystrophy. Clinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first 2 decades of life.,function:Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.,similarity:Belongs to the chaperonin (HSP60) family.,similarity:Belongs to the TCP-1 chaperonin family.,subunit:Interacts with HBV protein X and HTLV-1 protein p40tax.,
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