其他名称： ATP dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3X;CAP Rf;DBX;DDX14;DDX3X;DDX3X_HUMAN;DEAD (Asp Glu Ala Asp) box polypeptide 3 X linked;DEAD box;DEAD box protein 3;DEAD box protein 3 X-chromosomal;DEAD box X isoform;DEAD/H (Asp Glu Ala Asp/His) box polypeptide 3;DEAD/H box 3;DEAD/H box 3, X-linked;Fibroblast Growth Factor Inducible 14;Fin14;Helicase like protein 2;Helicase-like protein 2;HLP2;X isoform;X-chromosomal.
实测条带： 75kD
信号通路： RIG-I-like receptor;
功能： function:ATP-dependent RNA helicase. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. Also involved in HIV-1 replication. Interacts specifically with hepatitis C virus core protein resulting in a change in intracellular location.,similarity:Belongs to the DEAD box helicase family.,similarity:Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subcellular location:Located predominantly in nuclear speckles and, at low levels, throughout the cytoplasm. Located to the outer side of nuclear pore complexes (NPC). Shuttles between the nucleus and the cytoplasm in a XPO1-dependent manner.,subunit:Found in a complex with Rev and XPO1. Interacts with XPO1 and TDRD3. Interacts with HCV core protein.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane . Nucleus . Cytoplasm . Cytoplasm, Stress granule . Inflammasome . Cell projection, lamellipodium . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Shuttles between the nucleus and the cytosol (PubMed:15507209, PubMed:18636090, PubMed:29899501, PubMed:31575075, PubMed:30131165). Exported from the nucleus partly through the XPO1/CRM1 system and partly through NXF1/TAP (PubMed:15507209, PubMed:18636090, PubMed:18596238, PubMed:31575075, PubMed:30131165). Localizes to nuclear pores on the outer side of the nuclear membrane (PubMed:15507209). In the cytosol, partly colocalizes with mitochondria (PubMed:20127681). At G0, predominantly located in nucleus. In G1/S phase, predominantly cytoplasmic (PubMed:22034099). During prophase/prometaphase, localizes in close proximity to the condensing chromosomes (PubMed:30131165, PubMed:21730191). During telophase, localizes around the newly synthesized nuclear membrane and in the cytoplasm (PubMed:22034099). Colocalizes with TRPV4 at the plasma membrane. When TRPV4 channel is activated, intracellular Ca(2+) levels increase and the calmodulin/CAMKII pathway is activated, relocalizes to the nucleus (PubMed:29899501). WNT3A stimulation promotes DDX3 recruitment to the plasma membrane (PubMed:23413191). At the leading edge of migrating fibroblasts, colocalizes with CAPRIN1 and PABPC1 (PubMed:28733330). Localizes to centrosome throughout the cell cycle and associates with TP53 at centrosome during mitosis (PubMed:28842590). Translocates to the nucleus in response to HPIV-3 virus-mediated infection (PubMed:31575075). .
组织表达： Widely expressed (PubMed:15294876). In testis, expressed in spermatids (PubMed:15294876). Expressed in epidermis and liver (at protein level) (PubMed:16818630, PubMed:16301996).
其他名称： ATP dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3X;CAP Rf;DBX;DDX14;DDX3X;DDX3X_HUMAN;DEAD (Asp Glu Ala Asp) box polypeptide 3 X linked;DEAD box;DEAD box protein 3;DEAD box protein 3 X-chromosomal;DEAD box X isoform;DEAD/H (Asp Glu Ala Asp/His) box polypeptide 3;DEAD/H box 3;DEAD/H box 3, X-linked;Fibroblast Growth Factor Inducible 14;Fin14;Helicase like protein 2;Helicase-like protein 2;HLP2;X isoform;X-chromosomal.
实测条带： 75kD
信号通路： RIG-I-like receptor;
功能： function:ATP-dependent RNA helicase. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. Also involved in HIV-1 replication. Interacts specifically with hepatitis C virus core protein resulting in a change in intracellular location.,similarity:Belongs to the DEAD box helicase family.,similarity:Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subcellular location:Located predominantly in nuclear speckles and, at low levels, throughout the cytoplasm. Located to the outer side of nuclear pore complexes (NPC). Shuttles between the nucleus and the cytoplasm in a XPO1-dependent manner.,subunit:Found in a complex with Rev and XPO1. Interacts with XPO1 and TDRD3. Interacts with HCV core protein.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane . Nucleus . Cytoplasm . Cytoplasm, Stress granule . Inflammasome . Cell projection, lamellipodium . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Shuttles between the nucleus and the cytosol (PubMed:15507209, PubMed:18636090, PubMed:29899501, PubMed:31575075, PubMed:30131165). Exported from the nucleus partly through the XPO1/CRM1 system and partly through NXF1/TAP (PubMed:15507209, PubMed:18636090, PubMed:18596238, PubMed:31575075, PubMed:30131165). Localizes to nuclear pores on the outer side of the nuclear membrane (PubMed:15507209). In the cytosol, partly colocalizes with mitochondria (PubMed:20127681). At G0, predominantly located in nucleus. In G1/S phase, predominantly cytoplasmic (PubMed:22034099). During prophase/prometaphase, localizes in close proximity to the condensing chromosomes (PubMed:30131165, PubMed:21730191). During telophase, localizes around the newly synthesized nuclear membrane and in the cytoplasm (PubMed:22034099). Colocalizes with TRPV4 at the plasma membrane. When TRPV4 channel is activated, intracellular Ca(2+) levels increase and the calmodulin/CAMKII pathway is activated, relocalizes to the nucleus (PubMed:29899501). WNT3A stimulation promotes DDX3 recruitment to the plasma membrane (PubMed:23413191). At the leading edge of migrating fibroblasts, colocalizes with CAPRIN1 and PABPC1 (PubMed:28733330). Localizes to centrosome throughout the cell cycle and associates with TP53 at centrosome during mitosis (PubMed:28842590). Translocates to the nucleus in response to HPIV-3 virus-mediated infection (PubMed:31575075). .
组织表达： Widely expressed (PubMed:15294876). In testis, expressed in spermatids (PubMed:15294876). Expressed in epidermis and liver (at protein level) (PubMed:16818630, PubMed:16301996).
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