其他名称： AI849689 ;c Jun N terminal kinase 1 ;C-JUN kinase 1 ;c-Jun N-terminal kinase 1 ;EC 2.7.11.24 ;JAK 1A ;JAK1A ;JNK 1 ;JNK 46 ;JNK ;JNK-46 ;JNK1A2 ;JNK21B1/2 ;MAP kinase 8 ;MAPK 8 ;MAPK8 ;Mitogen activated protein kinase 8 ;Mitogen-activated protein kinase 8 ;MK08_HUMAN ;p54 gamma ;PRKM 8 ;PRKM8 ;Protein kinase JNK1 ;Protein kinase, mitogen-activated, 8 ;SAPK 1 ;SAPK gamma ;SAPK1 ;Stress activated protein kinase JNK1 ;Stress-activated protein kinase 1 ;Stress-activated protein kinase JNK1 ;Tyrosine protein kinase JAK1 .
实测条带： 46,54kD
信号通路： MAPK_ERK_Growth;MAPK_G_Protein;ErbB_HER;WNT;WNT-T CELLFocal adhesion;Toll_Like;NOD-like receptor;RIG-I-like receptor;Fc epsilon RI;Neurotrophin;Insulin_Receptor;GnRH;Progesterone-mediated oocyte maturation;Adipocytokine;Type II diabetes mellitus;Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Colorectal cancer;Pancreatic cancer;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. Inhibited by dual specificity phosphatases, such as DUSP1.,function:JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.,function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).,online information:C-Jun N-terminal kinases entry,PTM:Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP. Forms a complex with MAPK8IP1 and RGNEF (By similarity). Interacts with NFATC4.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Cell junction, synapse . In the cortical neurons, predominantly cytoplasmic and associated with the Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses (By similarity). Colocalizes with POU5F1 in the nucleus. .
其他名称： AI849689 ;c Jun N terminal kinase 1 ;C-JUN kinase 1 ;c-Jun N-terminal kinase 1 ;EC 2.7.11.24 ;JAK 1A ;JAK1A ;JNK 1 ;JNK 46 ;JNK ;JNK-46 ;JNK1A2 ;JNK21B1/2 ;MAP kinase 8 ;MAPK 8 ;MAPK8 ;Mitogen activated protein kinase 8 ;Mitogen-activated protein kinase 8 ;MK08_HUMAN ;p54 gamma ;PRKM 8 ;PRKM8 ;Protein kinase JNK1 ;Protein kinase, mitogen-activated, 8 ;SAPK 1 ;SAPK gamma ;SAPK1 ;Stress activated protein kinase JNK1 ;Stress-activated protein kinase 1 ;Stress-activated protein kinase JNK1 ;Tyrosine protein kinase JAK1 .
实测条带： 46,54kD
信号通路： MAPK_ERK_Growth;MAPK_G_Protein;ErbB_HER;WNT;WNT-T CELLFocal adhesion;Toll_Like;NOD-like receptor;RIG-I-like receptor;Fc epsilon RI;Neurotrophin;Insulin_Receptor;GnRH;Progesterone-mediated oocyte maturation;Adipocytokine;Type II diabetes mellitus;Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Colorectal cancer;Pancreatic cancer;
功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. Inhibited by dual specificity phosphatases, such as DUSP1.,function:JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.,function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).,online information:C-Jun N-terminal kinases entry,PTM:Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP. Forms a complex with MAPK8IP1 and RGNEF (By similarity). Interacts with NFATC4.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm . Nucleus . Cell junction, synapse . In the cortical neurons, predominantly cytoplasmic and associated with the Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses (By similarity). Colocalizes with POU5F1 in the nucleus. .
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