其他名称： Ac2-121;AL022808;E3 ubiquitin-protein ligase UHRF1;EC 6.3.2.-;FLJ21925;Hnp95 Huhrf1; HuNp95;ICBP90;Inverted CCAAT box binding protein of 90 kDa;Inverted CCAAT box binding protein, 90-Kd;Inverted CCAAT box-binding protein of 90 kDa;Liver regeneration-related protein LRRG126;MGC138707;NP95;Nuclear phosphoprotein, 95-KD;Nuclear protein 95;Nuclear zinc finger protein Np95;RING finger protein 106;RNF106;Transcription factor ICBP90; Ubiquitin like containing PHD and RING finger domains protein 1;Ubiquitin like PHD and RING finger domain containing protein 1;Ubiquitin-like PHD and RING finger domain-containing protein 1;Ubiquitin-like protein containing PHD and RING finger domains 1; Ubiquitin-like with PHD and ring finger domains 1;Ubiquitin-like, containing PHD and RING finger domains, 1;Ubiquitin-like-containing PHD and RING finger domains protein 1;UHRF1;UHRF1_HUMAN.
实测条带： 90kD
功能： developmental stage:Expressed in fetal thymus, liver and kidney.,domain:The RING finger is required for ubiquitin ligase activity.,domain:The YDG domain mediates the interaction with histone H3.,function:Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.,induction:Up-regulated in proliferating cells, and down-regulated in quiescent cells. Down-regulated upon adriamycin-induced DNA damage, in a TP53/p53 and CDKN1A-dependent way. Induced by E2F1 transcription factor.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated on serine residues. Phosphorylation may enhance DNA-binding activity.,PTM:Ubiquitinated; which leads to proteasomal degradation. Polyubiquitination may be stimulated by DNA damage.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 ubiquitin-like domain.,similarity:Contains 1 YDG domain.,similarity:Contains 2 RING-type zinc fingers.,subunit:Interacts with histones H3, H1 and H2B (By similarity). Interacts with HDAC1, but not with HDAC2. Interacts with UHRF1BP1. Binds methylated CpG containing oligonucleotides.,tissue specificity:Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.,
其他名称： Ac2-121;AL022808;E3 ubiquitin-protein ligase UHRF1;EC 6.3.2.-;FLJ21925;Hnp95 Huhrf1; HuNp95;ICBP90;Inverted CCAAT box binding protein of 90 kDa;Inverted CCAAT box binding protein, 90-Kd;Inverted CCAAT box-binding protein of 90 kDa;Liver regeneration-related protein LRRG126;MGC138707;NP95;Nuclear phosphoprotein, 95-KD;Nuclear protein 95;Nuclear zinc finger protein Np95;RING finger protein 106;RNF106;Transcription factor ICBP90; Ubiquitin like containing PHD and RING finger domains protein 1;Ubiquitin like PHD and RING finger domain containing protein 1;Ubiquitin-like PHD and RING finger domain-containing protein 1;Ubiquitin-like protein containing PHD and RING finger domains 1; Ubiquitin-like with PHD and ring finger domains 1;Ubiquitin-like, containing PHD and RING finger domains, 1;Ubiquitin-like-containing PHD and RING finger domains protein 1;UHRF1;UHRF1_HUMAN.
实测条带： 90kD
功能： developmental stage:Expressed in fetal thymus, liver and kidney.,domain:The RING finger is required for ubiquitin ligase activity.,domain:The YDG domain mediates the interaction with histone H3.,function:Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.,induction:Up-regulated in proliferating cells, and down-regulated in quiescent cells. Down-regulated upon adriamycin-induced DNA damage, in a TP53/p53 and CDKN1A-dependent way. Induced by E2F1 transcription factor.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated on serine residues. Phosphorylation may enhance DNA-binding activity.,PTM:Ubiquitinated; which leads to proteasomal degradation. Polyubiquitination may be stimulated by DNA damage.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 ubiquitin-like domain.,similarity:Contains 1 YDG domain.,similarity:Contains 2 RING-type zinc fingers.,subunit:Interacts with histones H3, H1 and H2B (By similarity). Interacts with HDAC1, but not with HDAC2. Interacts with UHRF1BP1. Binds methylated CpG containing oligonucleotides.,tissue specificity:Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.,
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