其他名称: TBL1XR1; IRA1; TBLR1; F-box-like/WD repeat-containing protein TBL1XR1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1
信号通路: WNT;WNT-T CELL
功能: domain:The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.,function:F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the WD repeat EBI family.,similarity:Contains 1 F-box-like domain.,similarity:Contains 1 LisH domain.,similarity:Contains 8 WD repeats.,subunit:Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4.,tissue specificity:Ubiquitous.,
相关产品: YM1250,YM1102,RS0001,RS0002,YM3028,YM3029
细胞定位: Nucleus .
组织表达: Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver.
科研货号: PLA005158
TBL1XR1 Monoclonal Antibody
Catalog NoPLA005158
Product information
发货日期: 7
基因名称: TBL1XR1
蛋白名称: F-box-like/WD repeat-containing protein TBL1XR1
其他名称: TBL1XR1; IRA1; TBLR1; F-box-like/WD repeat-containing protein TBL1XR1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1
信号通路: WNT;WNT-T CELL
功能: domain:The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.,function:F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the WD repeat EBI family.,similarity:Contains 1 F-box-like domain.,similarity:Contains 1 LisH domain.,similarity:Contains 8 WD repeats.,subunit:Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4.,tissue specificity:Ubiquitous.,
相关产品: YM1250,YM1102,RS0001,RS0002,YM3028,YM3029
细胞定位: Nucleus .
组织表达: Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver.