信号通路： Proteasome;Antigen processing and presentation;
功能： disease:Sera from patients with systemic lupus erythematosus often contain antibodies that react with the Ki antigen.,domain:The C-terminal sequences affect heptamer stability and proteasome affinity.,function:Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-TP53/p53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of TP53/p53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.,induction:Up-regulated in thyroid carcinoma cells.,PTM:Phosphorylated by MAP3K3.,similarity:Belongs to the PA28 family.,subcellular location:Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase.,subunit:Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome. Interacts with TP53/p53 and MDM2. Interacts with MAP3K3 (By similarity). Associates with the proteasome.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. .
信号通路： Proteasome;Antigen processing and presentation;
功能： disease:Sera from patients with systemic lupus erythematosus often contain antibodies that react with the Ki antigen.,domain:The C-terminal sequences affect heptamer stability and proteasome affinity.,function:Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-TP53/p53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of TP53/p53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.,induction:Up-regulated in thyroid carcinoma cells.,PTM:Phosphorylated by MAP3K3.,similarity:Belongs to the PA28 family.,subcellular location:Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase.,subunit:Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome. Interacts with TP53/p53 and MDM2. Interacts with MAP3K3 (By similarity). Associates with the proteasome.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. .
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