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BACE Monoclonal Antibody
商品货号: PLA005095
适 应 性: 人,大鼠,牛,狗,猪
WB
¥600元
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MSDS
说明书
商品描述
  • 发货日期: 7
  • 基因名称: BACE1
  • 蛋白名称: Beta-secretase 1
  • Human_gene_id: 23621
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23621
  • Human_swiss_prot_no: P56817
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P56817/entry
  • Mouse_swiss_prot_no: P56818
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P56818
  • Rat_gene_id: 29392
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29392
  • Rat_swiss_prot_no: P56819
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P56819
  • 特异性: BACE Monoclonal Antibody detects endogenous levels of BACE protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Monoclonal, Mouse
  • 稀释: WB 1:1000 - 1:2000. Not yet tested in other applications.
  • 纯化工艺: Affinity purification
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
  • 信号通路: Alzheimer's disease;
  • 功能: catalytic activity:Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.,enzyme regulation:Inhibited by RTN3 and RTN4.,function:Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.,similarity:Belongs to the peptidase A1 family.,subunit:Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4.,tissue specificity:Brain.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cell membrane ; Single-pass type I membrane protein . Golgi apparatus, trans-Golgi network . Endoplasmic reticulum . Endosome . Cell surface . Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Membrane raft . Lysosome . Late endosome . Early endosome . Recycling endosome . Cell projection, axon . Cell projection, dendrite . Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (PubMed:17425515, PubMed:11466313). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (By similarity). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (PubMed:15886016). .
  • 组织表达: Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
  • 科研货号: PLA005095
BACE Monoclonal Antibody
Catalog No PLA005095
Product information
  • 发货日期: 7
  • 基因名称: BACE1
  • 蛋白名称: Beta-secretase 1
  • Human_gene_id: 23621
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23621
  • Human_swiss_prot_no: P56817
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P56817/entry
  • Mouse_swiss_prot_no: P56818
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P56818
  • Rat_gene_id: 29392
  • Rat_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29392
  • Rat_swiss_prot_no: P56819
  • Rat_swiss_link: http://www.uniprot.org/uniprot/P56819
  • 特异性: BACE Monoclonal Antibody detects endogenous levels of BACE protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Monoclonal, Mouse
  • 稀释: WB 1:1000 - 1:2000. Not yet tested in other applications.
  • 纯化工艺: Affinity purification
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
  • 信号通路: Alzheimer's disease;
  • 功能: catalytic activity:Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.,enzyme regulation:Inhibited by RTN3 and RTN4.,function:Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.,similarity:Belongs to the peptidase A1 family.,subunit:Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4.,tissue specificity:Brain.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cell membrane ; Single-pass type I membrane protein . Golgi apparatus, trans-Golgi network . Endoplasmic reticulum . Endosome . Cell surface . Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Membrane raft . Lysosome . Late endosome . Early endosome . Recycling endosome . Cell projection, axon . Cell projection, dendrite . Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (PubMed:17425515, PubMed:11466313). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (By similarity). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (PubMed:15886016). .
  • 组织表达: Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
  • 科研货号: PLA005095
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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