Actinin-α2 Monoclonal Antibody

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商品货号： PLA005087

适应性： 人,大鼠,牛,鸡,狗,猪,斑马鱼

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

发货日期： 7
基因名称： ACTN2/ACTN3
蛋白名称： Alpha-actinin-2
Human_gene_id： 88
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=88
Human_swiss_prot_no： P35609
Human_swiss_link： http://www.uniprot.org/uniprotkb/P35609/entry
Mouse_swiss_prot_no： Q9JI91
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9JI91
特异性： Actinin-α2 Monoclonal Antibody detects endogenous levels of Actinin-α2 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Monoclonal, Mouse
稀释： WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
纯化工艺： Affinity purification
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ACTN2; Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein
信号通路： Focal adhesion;Adherens_Junction;Adherens_Junction;Leukocyte transendothelial migration;Regulates Actin and Cytoskeleton;Systemic lupus erythematosus;Arrhythmogenic right ventricular cardiomyopathy (ARVC);
功能： disease:Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:612158]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,function:F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.,similarity:Belongs to the alpha-actinin family.,similarity:Contains 1 actin-binding domain.,similarity:Contains 2 CH (calponin-homology) domains.,similarity:Contains 2 EF-hand domains.,similarity:Contains 4 spectrin repeats.,subcellular location:Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.,subunit:Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal region with the LDB3 PDZ domain. Interacts with XIRP2.,tissue specificity:Expressed in both skeletal and cardiac muscle.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, myofibril, sarcomere, Z line . Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
组织表达： Expressed in both skeletal and cardiac muscle.
科研货号： PLA005087

Actinin-α2 Monoclonal Antibody

Catalog No PLA005087

Product information

发货日期： 7
基因名称： ACTN2/ACTN3
蛋白名称： Alpha-actinin-2
Human_gene_id： 88
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=88
Human_swiss_prot_no： P35609
Human_swiss_link： http://www.uniprot.org/uniprotkb/P35609/entry
Mouse_swiss_prot_no： Q9JI91
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9JI91
特异性： Actinin-α2 Monoclonal Antibody detects endogenous levels of Actinin-α2 protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Monoclonal, Mouse
稀释： WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
纯化工艺： Affinity purification
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： ACTN2; Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein
信号通路： Focal adhesion;Adherens_Junction;Adherens_Junction;Leukocyte transendothelial migration;Regulates Actin and Cytoskeleton;Systemic lupus erythematosus;Arrhythmogenic right ventricular cardiomyopathy (ARVC);
功能： disease:Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:612158]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,function:F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.,similarity:Belongs to the alpha-actinin family.,similarity:Contains 1 actin-binding domain.,similarity:Contains 2 CH (calponin-homology) domains.,similarity:Contains 2 EF-hand domains.,similarity:Contains 4 spectrin repeats.,subcellular location:Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.,subunit:Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal region with the LDB3 PDZ domain. Interacts with XIRP2.,tissue specificity:Expressed in both skeletal and cardiac muscle.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cytoplasm, myofibril, sarcomere, Z line . Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
组织表达： Expressed in both skeletal and cardiac muscle.
科研货号： PLA005087

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