其他名称： GFI1; ZNF163; Zinc finger protein Gfi-1; Growth factor independent protein 1; Zinc finger protein 163
功能： disease:Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) [MIM:202700].,disease:Defects in GFI1 are a cause of dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) [MIM:607847]. NI-CINA is a relatively mild form of neutropenia diagnosed in adults, but predisposing to leukemia in a subset of patients.,domain:The Gly/Ala-rich region may indicate that Gfi-1 is a repressor of its target genes.,function:May be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. May be involved in tumor progression (By similarity). Represses ELA2 transcription.,online information:GFI1 mutation db,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with U2AF1L4.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.
其他名称： GFI1; ZNF163; Zinc finger protein Gfi-1; Growth factor independent protein 1; Zinc finger protein 163
功能： disease:Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) [MIM:202700].,disease:Defects in GFI1 are a cause of dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) [MIM:607847]. NI-CINA is a relatively mild form of neutropenia diagnosed in adults, but predisposing to leukemia in a subset of patients.,domain:The Gly/Ala-rich region may indicate that Gfi-1 is a repressor of its target genes.,function:May be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. May be involved in tumor progression (By similarity). Represses ELA2 transcription.,online information:GFI1 mutation db,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with U2AF1L4.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.
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