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Fyn Monoclonal Antibody
商品货号: PLA004819
适 应 性: 人,小鼠
WB ELISA
¥600元
规格:
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MSDS
说明书
商品描述
  • 发货日期: 7
  • 基因名称: FYN
  • 蛋白名称: Tyrosine-protein kinase Fyn
  • Human_gene_id: 2534
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2534
  • Human_swiss_prot_no: P06241
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P06241/entry
  • Mouse_gene_id: 14360
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14360
  • Mouse_swiss_prot_no: P39688
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P39688
  • 特异性: Fyn Monoclonal Antibody detects endogenous levels of Fyn protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Monoclonal, Mouse
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
  • 纯化工艺: Affinity purification
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: FYN; Tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn
  • 信号通路: Axon guidance;Focal adhesion;Adherens_Junction;Natural killer cell mediated cytotoxicity;T_Cell_Receptor;Fc epsilon RI;Prion diseases;Pathogenic Escherichia coli infection;Viral myocarditis;
  • 功能: catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,cofactor:Manganese.,enzyme regulation:Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.,function:Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.,subunit:Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase. Interacts with the FYN-binding protein (FYB). Interacts with phosphorylated TOM1L1. Interacts with CD79A upon activation of the B-cell antigen receptor which increases FYN activity (By similarity). Interacts with PAG1. Interacts (via SH3 domain) with PRMT8. Interacts with SH2D1A and SLAMF1. Interacts (via SH3 domain) with HEV ORF3 protein.,tissue specificity:Isoform 1 is highly expressed in the brain, isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.
  • 组织表达: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes.
  • 科研货号: PLA004819
Fyn Monoclonal Antibody
Catalog No PLA004819
Product information
  • 发货日期: 7
  • 基因名称: FYN
  • 蛋白名称: Tyrosine-protein kinase Fyn
  • Human_gene_id: 2534
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2534
  • Human_swiss_prot_no: P06241
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P06241/entry
  • Mouse_gene_id: 14360
  • Mouse_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14360
  • Mouse_swiss_prot_no: P39688
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P39688
  • 特异性: Fyn Monoclonal Antibody detects endogenous levels of Fyn protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Monoclonal, Mouse
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
  • 纯化工艺: Affinity purification
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: FYN; Tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn
  • 信号通路: Axon guidance;Focal adhesion;Adherens_Junction;Natural killer cell mediated cytotoxicity;T_Cell_Receptor;Fc epsilon RI;Prion diseases;Pathogenic Escherichia coli infection;Viral myocarditis;
  • 功能: catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,cofactor:Manganese.,enzyme regulation:Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.,function:Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.,subunit:Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase. Interacts with the FYN-binding protein (FYB). Interacts with phosphorylated TOM1L1. Interacts with CD79A upon activation of the B-cell antigen receptor which increases FYN activity (By similarity). Interacts with PAG1. Interacts (via SH3 domain) with PRMT8. Interacts with SH2D1A and SLAMF1. Interacts (via SH3 domain) with HEV ORF3 protein.,tissue specificity:Isoform 1 is highly expressed in the brain, isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.
  • 组织表达: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes.
  • 科研货号: PLA004819
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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