功能： catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in EPHB2 are involved in the development of prostate cancer metastasis to the brain [MIM:603688].,disease:Defects in EPHB2 are involved in the progression of prostate cancer [MIM:176807].,function:Receptor for members of the ephrin-B family. Acts as a tumor suppressor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:The ligand-activated form interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain. Binds RASGAP through the juxtamembrane tyrosines residues. Interacts with PRKCABP and GRIP1.,tissue specificity:Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane; Single-pass type I membrane protein. Cell projection, axon . Cell projection, dendrite .
组织表达： Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
功能： catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in EPHB2 are involved in the development of prostate cancer metastasis to the brain [MIM:603688].,disease:Defects in EPHB2 are involved in the progression of prostate cancer [MIM:176807].,function:Receptor for members of the ephrin-B family. Acts as a tumor suppressor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:The ligand-activated form interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain. Binds RASGAP through the juxtamembrane tyrosines residues. Interacts with PRKCABP and GRIP1.,tissue specificity:Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane; Single-pass type I membrane protein. Cell projection, axon . Cell projection, dendrite .
组织表达： Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
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