BMPR-II Monoclonal Antibody

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商品货号： PLA004670

适应性： 人,小鼠,大鼠,猴

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

发货日期： 7
基因名称： BMPR2
蛋白名称： Bone morphogenetic protein receptor type-2
Human_gene_id： 659
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=659
Human_swiss_prot_no： Q13873
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13873/entry
Mouse_gene_id： 12168
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12168
Mouse_swiss_prot_no： O35607
Mouse_swiss_link： http://www.uniprot.org/uniprot/O35607
特异性： BMPR-II Monoclonal Antibody detects endogenous levels of BMPR-II protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Monoclonal, Mouse
稀释： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： Affinity purification
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： BMPR2; PPH1; Bone morphogenetic protein receptor type-2; BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II
信号通路： Cytokine-cytokine receptor interaction;TGF-beta;
功能： catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,disease:Defects in BMPR2 are a cause of pulmonary venoocclusive disease (PVOD) [MIM:265450]. PVOD is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with PPH1 has been speculative. The finding of PVOD associated with a BMPR2 mutation reveals a possible pathogenetic connection with PPH1.,disease:Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1) [MIM:178600]. PPH1 is a rare autosomal dominant disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highly expressed in heart and liver.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein.
组织表达： Highly expressed in heart and liver.
科研货号： PLA004670

BMPR-II Monoclonal Antibody

Catalog No PLA004670

Product information

发货日期： 7
基因名称： BMPR2
蛋白名称： Bone morphogenetic protein receptor type-2
Human_gene_id： 659
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=659
Human_swiss_prot_no： Q13873
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13873/entry
Mouse_gene_id： 12168
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12168
Mouse_swiss_prot_no： O35607
Mouse_swiss_link： http://www.uniprot.org/uniprot/O35607
特异性： BMPR-II Monoclonal Antibody detects endogenous levels of BMPR-II protein.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Monoclonal, Mouse
稀释： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： Affinity purification
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： BMPR2; PPH1; Bone morphogenetic protein receptor type-2; BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; BMP type II receptor; BMPR-II
信号通路： Cytokine-cytokine receptor interaction;TGF-beta;
功能： catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,disease:Defects in BMPR2 are a cause of pulmonary venoocclusive disease (PVOD) [MIM:265450]. PVOD is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with PPH1 has been speculative. The finding of PVOD associated with a BMPR2 mutation reveals a possible pathogenetic connection with PPH1.,disease:Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1) [MIM:178600]. PPH1 is a rare autosomal dominant disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highly expressed in heart and liver.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Cell membrane ; Single-pass type I membrane protein.
组织表达： Highly expressed in heart and liver.
科研货号： PLA004670

Hunan UPT Biotechnology Co.,Ltd

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E-mail：service@uptbio.com

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