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PROC (light chain, Cleaved-Leu179) rabbit pAb
商品货号: PLA004481
适 应 性: 人,大鼠,小鼠,
WB IHC ELISA
¥600元
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MSDS
说明书
商品描述
  • 基因名称: PROC
  • 蛋白名称: PROC (light chain, Cleaved-Leu179)
  • Human_gene_id: 5624
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5624
  • Human_swiss_prot_no: P04070
  • Human_swiss_link: https://www.uniprot.org/uniprotkb/P04070/entry
  • Mouse_gene_id: 19123
  • Mouse_gene_link: https://www.uniprot.org/uniprot/19123
  • Mouse_swiss_prot_no: P33587
  • Mouse_swiss_link: https://www.uniprot.org/uniprotkb/P33587
  • Rat_gene_id: 25268
  • Rat_gene_link: https://www.uniprot.org/uniprot/25268
  • Rat_swiss_prot_no: P31394
  • Rat_swiss_link: https://www.uniprot.org/uniprotkb/P31394
  • 特异性: This antibody detects endogenous levels of Human PROC (light chain, Cleaved-Leu179, protein was cleaved amino acid sequence between 179-180 )
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: Vitamin K-dependent protein C (EC 3.4.21.69;Anticoagulant protein C;Autoprothrombin IIA;Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]
  • 实测条带: 17 45kD
  • 功能: catalytic activity:Degradation of blood coagulation factors Va and VIIIa.,disease:Defects in PROC are the cause of protein C deficiency autosomal dominant (ADPROCD) [MIM:176860]. ADPROCD is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency.,disease:Defects in PROC are the cause of protein C deficiency autosomal recessive (ARPROCD) [MIM:612304]. ARPROCD results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare.,function:Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.,miscellaneous:Calcium also binds, with stronger affinity to another site, beyond the GLA domain. This GLA-independent binding site is necessary for the recognition of the thrombin-thrombomodulin complex.,online information:Protein C entry,PTM:Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not glycosylated at Asn-371, is beta.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,PTM:The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.,sequence caution:Translated as Cys.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,subunit:Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.,tissue specificity:Plasma; synthesized in the liver.,
  • 相关产品: RS0001,RS0002,YM3028,YM3128
  • 细胞定位: Secreted . Golgi apparatus . Endoplasmic reticulum .
  • 组织表达: Plasma; synthesized in the liver.
  • 科研货号: PLA004481
PROC (light chain, Cleaved-Leu179) rabbit pAb
Catalog No PLA004481
Product information
  • 基因名称: PROC
  • 蛋白名称: PROC (light chain, Cleaved-Leu179)
  • Human_gene_id: 5624
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5624
  • Human_swiss_prot_no: P04070
  • Human_swiss_link: https://www.uniprot.org/uniprotkb/P04070/entry
  • Mouse_gene_id: 19123
  • Mouse_gene_link: https://www.uniprot.org/uniprot/19123
  • Mouse_swiss_prot_no: P33587
  • Mouse_swiss_link: https://www.uniprot.org/uniprotkb/P33587
  • Rat_gene_id: 25268
  • Rat_gene_link: https://www.uniprot.org/uniprot/25268
  • Rat_swiss_prot_no: P31394
  • Rat_swiss_link: https://www.uniprot.org/uniprotkb/P31394
  • 特异性: This antibody detects endogenous levels of Human PROC (light chain, Cleaved-Leu179, protein was cleaved amino acid sequence between 179-180 )
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: Vitamin K-dependent protein C (EC 3.4.21.69;Anticoagulant protein C;Autoprothrombin IIA;Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]
  • 实测条带: 17 45kD
  • 功能: catalytic activity:Degradation of blood coagulation factors Va and VIIIa.,disease:Defects in PROC are the cause of protein C deficiency autosomal dominant (ADPROCD) [MIM:176860]. ADPROCD is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency.,disease:Defects in PROC are the cause of protein C deficiency autosomal recessive (ARPROCD) [MIM:612304]. ARPROCD results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare.,function:Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.,miscellaneous:Calcium also binds, with stronger affinity to another site, beyond the GLA domain. This GLA-independent binding site is necessary for the recognition of the thrombin-thrombomodulin complex.,online information:Protein C entry,PTM:Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not glycosylated at Asn-371, is beta.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,PTM:The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.,sequence caution:Translated as Cys.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,subunit:Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.,tissue specificity:Plasma; synthesized in the liver.,
  • 相关产品: RS0001,RS0002,YM3028,YM3128
  • 细胞定位: Secreted . Golgi apparatus . Endoplasmic reticulum .
  • 组织表达: Plasma; synthesized in the liver.
  • 科研货号: PLA004481
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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