PROC (light chain, Cleaved-Leu179) rabbit pAb

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商品货号： PLA004481

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： PROC
蛋白名称： PROC (light chain, Cleaved-Leu179)
Human_gene_id： 5624
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5624
Human_swiss_prot_no： P04070
Human_swiss_link： https://www.uniprot.org/uniprotkb/P04070/entry
Mouse_gene_id： 19123
Mouse_gene_link： https://www.uniprot.org/uniprot/19123
Mouse_swiss_prot_no： P33587
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P33587
Rat_gene_id： 25268
Rat_gene_link： https://www.uniprot.org/uniprot/25268
Rat_swiss_prot_no： P31394
Rat_swiss_link： https://www.uniprot.org/uniprotkb/P31394
特异性： This antibody detects endogenous levels of Human PROC (light chain, Cleaved-Leu179, protein was cleaved amino acid sequence between 179-180 )
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Vitamin K-dependent protein C (EC 3.4.21.69;Anticoagulant protein C;Autoprothrombin IIA;Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]
实测条带： 17 45kD
功能： catalytic activity:Degradation of blood coagulation factors Va and VIIIa.,disease:Defects in PROC are the cause of protein C deficiency autosomal dominant (ADPROCD) [MIM:176860]. ADPROCD is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency.,disease:Defects in PROC are the cause of protein C deficiency autosomal recessive (ARPROCD) [MIM:612304]. ARPROCD results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare.,function:Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.,miscellaneous:Calcium also binds, with stronger affinity to another site, beyond the GLA domain. This GLA-independent binding site is necessary for the recognition of the thrombin-thrombomodulin complex.,online information:Protein C entry,PTM:Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not glycosylated at Asn-371, is beta.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,PTM:The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.,sequence caution:Translated as Cys.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,subunit:Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.,tissue specificity:Plasma; synthesized in the liver.,
相关产品： RS0001,RS0002,YM3028,YM3128
细胞定位： Secreted . Golgi apparatus . Endoplasmic reticulum .
组织表达： Plasma; synthesized in the liver.
科研货号： PLA004481

PROC (light chain, Cleaved-Leu179) rabbit pAb

Catalog No PLA004481

Product information

基因名称： PROC
蛋白名称： PROC (light chain, Cleaved-Leu179)
Human_gene_id： 5624
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5624
Human_swiss_prot_no： P04070
Human_swiss_link： https://www.uniprot.org/uniprotkb/P04070/entry
Mouse_gene_id： 19123
Mouse_gene_link： https://www.uniprot.org/uniprot/19123
Mouse_swiss_prot_no： P33587
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P33587
Rat_gene_id： 25268
Rat_gene_link： https://www.uniprot.org/uniprot/25268
Rat_swiss_prot_no： P31394
Rat_swiss_link： https://www.uniprot.org/uniprotkb/P31394
特异性： This antibody detects endogenous levels of Human PROC (light chain, Cleaved-Leu179, protein was cleaved amino acid sequence between 179-180 )
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Vitamin K-dependent protein C (EC 3.4.21.69;Anticoagulant protein C;Autoprothrombin IIA;Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]
实测条带： 17 45kD
功能： catalytic activity:Degradation of blood coagulation factors Va and VIIIa.,disease:Defects in PROC are the cause of protein C deficiency autosomal dominant (ADPROCD) [MIM:176860]. ADPROCD is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency.,disease:Defects in PROC are the cause of protein C deficiency autosomal recessive (ARPROCD) [MIM:612304]. ARPROCD results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare.,function:Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.,miscellaneous:Calcium also binds, with stronger affinity to another site, beyond the GLA domain. This GLA-independent binding site is necessary for the recognition of the thrombin-thrombomodulin complex.,online information:Protein C entry,PTM:Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not glycosylated at Asn-371, is beta.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,PTM:The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.,sequence caution:Translated as Cys.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,subunit:Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.,tissue specificity:Plasma; synthesized in the liver.,
相关产品： RS0001,RS0002,YM3028,YM3128
细胞定位： Secreted . Golgi apparatus . Endoplasmic reticulum .
组织表达： Plasma; synthesized in the liver.
科研货号： PLA004481

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