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NOTCH4 (Cleaved-Val1467) rabbit pAb
商品货号: PLA004477
适 应 性: 人,猴
WB ELISA
¥600元
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MSDS
说明书
商品描述
  • 基因名称: NOTCH4 INT3
  • 蛋白名称: NOTCH4 (Cleaved-Val1467)
  • Human_gene_id: 4855
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4855
  • Human_swiss_prot_no: Q99466
  • Human_swiss_link: https://www.uniprot.org/uniprotkb/Q99466/entry
  • Mouse_gene_id: 18132
  • Mouse_gene_link: https://www.uniprot.org/uniprot/18132
  • Mouse_swiss_prot_no: P31695
  • Mouse_swiss_link: https://www.uniprot.org/uniprotkb/P31695
  • 特异性: This antibody detects endogenous levels of Human,Monkey NOTCH4 (Cleaved-Val1467, protein was cleaved amino acid sequence between 1466-1467 )
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:1000-2000 ELISA 1:5000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: Neurogenic locus notch homolog protein 4 (Notch 4;hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain]
  • 实测条带: 60 220kD
  • 功能: alternative products:Experimental confirmation may be lacking for some isoforms,function:Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.,polymorphism:The poly-Leu region of NOTCH4 (in the signal peptide) is polymorphic and the number of Leu varies in the population (from 6 to 12).,PTM:Phosphorylated.,PTM:Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.,similarity:Belongs to the NOTCH family.,similarity:Contains 28 EGF-like domains.,similarity:Contains 3 LNR (Lin/Notch) repeats.,similarity:Contains 5 ANK repeats.,subcellular location:Following proteolytical processing NICD is translocated to the nucleus.,subunit:Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.,tissue specificity:Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.,
  • 相关产品: RS0001,RS0002,YM3028,YM3124
  • 细胞定位: Cell membrane; Single-pass type I membrane protein.; [Notch 4 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
  • 组织表达: Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
  • 科研货号: PLA004477
NOTCH4 (Cleaved-Val1467) rabbit pAb
Catalog No PLA004477
Product information
  • 基因名称: NOTCH4 INT3
  • 蛋白名称: NOTCH4 (Cleaved-Val1467)
  • Human_gene_id: 4855
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4855
  • Human_swiss_prot_no: Q99466
  • Human_swiss_link: https://www.uniprot.org/uniprotkb/Q99466/entry
  • Mouse_gene_id: 18132
  • Mouse_gene_link: https://www.uniprot.org/uniprot/18132
  • Mouse_swiss_prot_no: P31695
  • Mouse_swiss_link: https://www.uniprot.org/uniprotkb/P31695
  • 特异性: This antibody detects endogenous levels of Human,Monkey NOTCH4 (Cleaved-Val1467, protein was cleaved amino acid sequence between 1466-1467 )
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:1000-2000 ELISA 1:5000-20000
  • 纯化工艺: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: Neurogenic locus notch homolog protein 4 (Notch 4;hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain]
  • 实测条带: 60 220kD
  • 功能: alternative products:Experimental confirmation may be lacking for some isoforms,function:Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.,polymorphism:The poly-Leu region of NOTCH4 (in the signal peptide) is polymorphic and the number of Leu varies in the population (from 6 to 12).,PTM:Phosphorylated.,PTM:Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.,similarity:Belongs to the NOTCH family.,similarity:Contains 28 EGF-like domains.,similarity:Contains 3 LNR (Lin/Notch) repeats.,similarity:Contains 5 ANK repeats.,subcellular location:Following proteolytical processing NICD is translocated to the nucleus.,subunit:Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.,tissue specificity:Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.,
  • 相关产品: RS0001,RS0002,YM3028,YM3124
  • 细胞定位: Cell membrane; Single-pass type I membrane protein.; [Notch 4 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
  • 组织表达: Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
  • 科研货号: PLA004477
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    E-mail:service@uptbio.com
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