FA11 (heavy chain, Cleaved-Arg387) rabbit pAb

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商品货号： PLA004405

适应性： 人,小鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： F11
蛋白名称： FA11 (heavy chain, Cleaved-Arg387)
Human_gene_id： 2160
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2160
Human_swiss_prot_no： P03951
Human_swiss_link： https://www.uniprot.org/uniprotkb/P03951/entry
Mouse_gene_id： 109821
Mouse_gene_link： https://www.uniprot.org/uniprot/109821
Mouse_swiss_prot_no： Q91Y47
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q91Y47
特异性： This antibody detects endogenous levels of Human, Mouse FA11 (heavy chain, Cleaved-Arg387, protein was cleaved amino acid sequence between 387-388 )
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:1000-2000 ELISA 1:5000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Coagulation factor XI (FXI;EC 3.4.21.27;Plasma thromboplastin antecedent;PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]
实测条带： 40 66kD
功能： catalytic activity:Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.,disease:Defects in F11 are the cause of F11 deficiency [MIM:612416]; also called plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a blood coagulation abnormality occurring in high frequency in Ashkenazi jews. F11-deficient patients are prone to excessive bleeding after haemostatic challenge.,function:Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.,online information:Factor XI entry,PTM:Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.,similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 4 apple domains.,subunit:Homodimer; disulfide-linked. After activation the heavy and light chains are also linked by a disulfide bond.,tissue specificity:Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.,
相关产品： RS0001,RS0002,YM3028,YM3052
细胞定位： Secreted.
组织表达： Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
科研货号： PLA004405

FA11 (heavy chain, Cleaved-Arg387) rabbit pAb

Catalog No PLA004405

Product information

基因名称： F11
蛋白名称： FA11 (heavy chain, Cleaved-Arg387)
Human_gene_id： 2160
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2160
Human_swiss_prot_no： P03951
Human_swiss_link： https://www.uniprot.org/uniprotkb/P03951/entry
Mouse_gene_id： 109821
Mouse_gene_link： https://www.uniprot.org/uniprot/109821
Mouse_swiss_prot_no： Q91Y47
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q91Y47
特异性： This antibody detects endogenous levels of Human, Mouse FA11 (heavy chain, Cleaved-Arg387, protein was cleaved amino acid sequence between 387-388 )
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:1000-2000 ELISA 1:5000-20000
纯化工艺： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： Coagulation factor XI (FXI;EC 3.4.21.27;Plasma thromboplastin antecedent;PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]
实测条带： 40 66kD
功能： catalytic activity:Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.,disease:Defects in F11 are the cause of F11 deficiency [MIM:612416]; also called plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a blood coagulation abnormality occurring in high frequency in Ashkenazi jews. F11-deficient patients are prone to excessive bleeding after haemostatic challenge.,function:Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.,online information:Factor XI entry,PTM:Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.,similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 4 apple domains.,subunit:Homodimer; disulfide-linked. After activation the heavy and light chains are also linked by a disulfide bond.,tissue specificity:Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.,
相关产品： RS0001,RS0002,YM3028,YM3052
细胞定位： Secreted.
组织表达： Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
科研货号： PLA004405

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