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MMP-1 Polyclonal Antibody
商品货号: PLA004373
适 应 性: 人,大鼠,小鼠,
WB ELISA
¥600元
规格:
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MSDS
说明书
商品描述
  • 基因名称: MMP1
  • 蛋白名称: Interstitial collagenase
  • Human_gene_id: 4312
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4312
  • Human_swiss_prot_no: P03956
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P03956/entry
  • 特异性: MMP-1 Polyclonal Antibody detects endogenous levels of MMP-1 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: MMP1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1
  • 实测条带: 55kD
  • 信号通路: PPAR;Pathways in cancer;Bladder cancer;
  • 功能: catalytic activity:Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,domain:There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases).,enzyme regulation:Can be activated without removal of the activation peptide.,function:Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.,online information:Collagenase entry,PTM:Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subunit:Interacts with HIV-1 Tat.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Secreted, extracellular space, extracellular matrix .
  • 组织表达: Fibroblast,Ovary,Synovial cell,Synovial membrane,Thyroid,
  • 科研货号: PLA004373
MMP-1 Polyclonal Antibody
Catalog No PLA004373
Product information
  • 基因名称: MMP1
  • 蛋白名称: Interstitial collagenase
  • Human_gene_id: 4312
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4312
  • Human_swiss_prot_no: P03956
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P03956/entry
  • 特异性: MMP-1 Polyclonal Antibody detects endogenous levels of MMP-1 protein.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: MMP1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1
  • 实测条带: 55kD
  • 信号通路: PPAR;Pathways in cancer;Bladder cancer;
  • 功能: catalytic activity:Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,domain:There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases).,enzyme regulation:Can be activated without removal of the activation peptide.,function:Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.,online information:Collagenase entry,PTM:Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subunit:Interacts with HIV-1 Tat.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Secreted, extracellular space, extracellular matrix .
  • 组织表达: Fibroblast,Ovary,Synovial cell,Synovial membrane,Thyroid,
  • 科研货号: PLA004373
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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