Cleaved-MMP-17 (Q129) Polyclonal Antibody

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商品货号： PLA004338

适应性： 人,大鼠,小鼠,

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： MMP17
蛋白名称： Matrix metalloproteinase-17
Human_gene_id： 4326
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4326
Human_swiss_prot_no： Q9ULZ9
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9ULZ9/entry
Mouse_swiss_prot_no： Q9R0S3
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9R0S3
特异性： Cleaved-MMP-17 (Q129) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-17 protein resulting from cleavage adjacent to Q129.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MMP17; MT4MMP; Matrix metalloproteinase-17; MMP-17; Membrane-type matrix metalloproteinase 4; MT-MMP 4; MTMMP4; Membrane-type-4 matrix metalloproteinase; MT4-MMP; MT4MMP
实测条带： 53kD
信号通路： Angiogenesis
功能： catalytic activity:Cleaves pro-TNF-alpha at the 74-Ala-|-Gln-75 site.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform Long]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
组织表达： Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.
科研货号： PLA004338

Cleaved-MMP-17 (Q129) Polyclonal Antibody

Catalog No PLA004338

Product information

基因名称： MMP17
蛋白名称： Matrix metalloproteinase-17
Human_gene_id： 4326
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4326
Human_swiss_prot_no： Q9ULZ9
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9ULZ9/entry
Mouse_swiss_prot_no： Q9R0S3
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9R0S3
特异性： Cleaved-MMP-17 (Q129) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-17 protein resulting from cleavage adjacent to Q129.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MMP17; MT4MMP; Matrix metalloproteinase-17; MMP-17; Membrane-type matrix metalloproteinase 4; MT-MMP 4; MTMMP4; Membrane-type-4 matrix metalloproteinase; MT4-MMP; MT4MMP
实测条带： 53kD
信号通路： Angiogenesis
功能： catalytic activity:Cleaves pro-TNF-alpha at the 74-Ala-|-Gln-75 site.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： [Isoform Long]: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
组织表达： Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.
科研货号： PLA004338

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