Cleaved-MMP-14 (Y112) Polyclonal Antibody

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商品货号： PLA004336

适应性： 人,小鼠,大鼠

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

基因名称： MMP14
蛋白名称： Matrix metalloproteinase-14
Human_gene_id： 4323
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4323
Human_swiss_prot_no： P50281
Human_swiss_link： http://www.uniprot.org/uniprotkb/P50281/entry
Mouse_gene_id： 17387
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17387
Mouse_swiss_prot_no： P53690
Mouse_swiss_link： http://www.uniprot.org/uniprot/P53690
Rat_gene_id： 81707
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81707
Rat_swiss_prot_no： Q10739
Rat_swiss_link： http://www.uniprot.org/uniprot/Q10739
特异性： Cleaved-MMP-14 (Y112) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-14 protein resulting from cleavage adjacent to Y112.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MMP14; Matrix metalloproteinase-14; MMP-14; MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP
实测条带： 53kD
信号通路： GnRH;
功能： catalytic activity:Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,tissue specificity:In stromal cells of colon, breast, and head and neck.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane ; Single-pass type I membrane protein . Melanosome. Cytoplasm. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
组织表达： Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.
科研货号： PLA004336

Cleaved-MMP-14 (Y112) Polyclonal Antibody

Catalog No PLA004336

Product information

基因名称： MMP14
蛋白名称： Matrix metalloproteinase-14
Human_gene_id： 4323
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4323
Human_swiss_prot_no： P50281
Human_swiss_link： http://www.uniprot.org/uniprotkb/P50281/entry
Mouse_gene_id： 17387
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17387
Mouse_swiss_prot_no： P53690
Mouse_swiss_link： http://www.uniprot.org/uniprot/P53690
Rat_gene_id： 81707
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81707
Rat_swiss_prot_no： Q10739
Rat_swiss_link： http://www.uniprot.org/uniprot/Q10739
特异性： Cleaved-MMP-14 (Y112) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-14 protein resulting from cleavage adjacent to Y112.
组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
来源： Polyclonal, Rabbit,IgG
稀释： WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
纯化工艺： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度： 1 mg/ml
储存： -15°C to -25°C/1 year(Do not lower than -25°C)
说明书： 1
Msds： MSDS_Antibody.pdf
其他名称： MMP14; Matrix metalloproteinase-14; MMP-14; MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP
实测条带： 53kD
信号通路： GnRH;
功能： catalytic activity:Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,tissue specificity:In stromal cells of colon, breast, and head and neck.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Membrane ; Single-pass type I membrane protein . Melanosome. Cytoplasm. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
组织表达： Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.
科研货号： PLA004336

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