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Cleaved-MMP-12 (G106) Polyclonal Antibody
商品货号: PLA004335
适 应 性: 人,大鼠,小鼠,
WB ELISA
¥600元
规格:
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MSDS
说明书
商品描述
  • 基因名称: MMP12
  • 蛋白名称: Macrophage metalloelastase
  • Human_gene_id: 4321
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4321
  • Human_swiss_prot_no: P39900
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P39900/entry
  • Mouse_swiss_prot_no: P34960
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P34960
  • 特异性: Cleaved-MMP-12 (G106) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-12 protein resulting from cleavage adjacent to G106.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: MMP12; HME; Macrophage metalloelastase; MME; Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12
  • 实测条带: 42kD
  • 信号通路: Angiogenesis
  • 功能: catalytic activity:Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.,induction:By exposure to lipopolysaccharide. Inhibited by dexamethasone.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Found in alveolar macrophages but not in peripheral blood monocytes.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Secreted, extracellular space, extracellular matrix .
  • 组织表达: Found in alveolar macrophages but not in peripheral blood monocytes.
  • 科研货号: PLA004335
Cleaved-MMP-12 (G106) Polyclonal Antibody
Catalog No PLA004335
Product information
  • 基因名称: MMP12
  • 蛋白名称: Macrophage metalloelastase
  • Human_gene_id: 4321
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4321
  • Human_swiss_prot_no: P39900
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P39900/entry
  • Mouse_swiss_prot_no: P34960
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P34960
  • 特异性: Cleaved-MMP-12 (G106) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-12 protein resulting from cleavage adjacent to G106.
  • 组成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 来源: Polyclonal, Rabbit,IgG
  • 稀释: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
  • 纯化工艺: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度: 1 mg/ml
  • 储存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 说明书: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名称: MMP12; HME; Macrophage metalloelastase; MME; Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12
  • 实测条带: 42kD
  • 信号通路: Angiogenesis
  • 功能: catalytic activity:Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.,induction:By exposure to lipopolysaccharide. Inhibited by dexamethasone.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Found in alveolar macrophages but not in peripheral blood monocytes.,
  • 相关产品: RS0001,RS0002,YM3028,YM3029
  • 细胞定位: Secreted, extracellular space, extracellular matrix .
  • 组织表达: Found in alveolar macrophages but not in peripheral blood monocytes.
  • 科研货号: PLA004335
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.uptbio.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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